FB2024_03 , released June 25, 2024
Allele: Dmel\cal1c03646
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General Information
Symbol
Dmel\cal1c03646
Species
D. melanogaster
Name
FlyBase ID
FBal0161320
Feature type
allele
Associated gene
Dmel\cal1
Associated Insertion(s)
PBac{PB}cal1c03646
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{PB}cal1c03646
Cytology
Description

Insertion 69bp upstream of the start codon, within the predicted 5' untranslated region.

(Schittenhelm et al., 2010)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos first show abnormalities during stage 12. At this and later stages, defects are mostly restricted to the developing central nervous system which contains a lower number and more irregular distribution of nuclei compared to in controls. In addition, pyknotic and enlarged, over-replicated nuclei are also seen in the mutant central nervous system.

      (Schittenhelm et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      cal1MB04866

      (Schittenhelm et al., 2010)
      Rescued by

      cal1c03646 is rescued by cal1EGFP

      (Lehner, 2020.12.4)
      Comments

      Expression of one of cal1N.Scer\UAS.T:Avic\GFP-EGFP, cal1M.Scer\UAS.T:Avic\GFP-EGFP or cal1C.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4sca-537.4 fails to rescue normal cell proliferation in cal1unspecified embryos.

      Co-expression of both cal1N.Scer\UAS.T:Avic\GFP-EGFP and cal1C.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4sca-537.4 fails to rescue normal cell proliferation in cal1unspecified embryos.

      Expression of either cal1Scer\UAS.T:Avic\GFP-EGFP or cal1N-C.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4sca-537.4 rescues normal cell proliferation in cal1unspecified embryos.

      (Schittenhelm et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG5148c03646
      cal1c03646
      (Lehner, 2020.12.4, Zhao et al., 2019, Schittenhelm et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)