FlyBase Allele Report: Dmel\Gas41[f05565]

General Information

Symbol

Dmel\Gas41^f05565

Species

D. melanogaster

Name

FlyBase ID

FBal0160835

Feature type

allele

Associated gene

Dmel\Gas41

Associated Insertion(s)

PBac{WH}Gas41^f05565

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

piggyBac activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Gandhi et al., 2015)

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{WH}Gas41^f05565

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:6,949,965..6,949,965 [-]

(Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

majority die during first instar larval stage | recessive

(Gandhi et al., 2015)

melanotic necrosis | adult stage

(Gandhi et al., 2015)

suppressor of variegation, with T(2;3)Sb^V

(Gandhi et al., 2015)

Phenotype Manifest In

scutellum

(Gandhi et al., 2015)

scutum

(Gandhi et al., 2015)

Detailed Description

Statement

Reference

Gas41^f05565 homozygotes die at first larval instar stage, the few escapers that survive to adulthood show a necrotic phenotype with necrotic patches observed in the scutum, notum and scutellum regions.

Combination with a single copy of Gas41^f05565 also partially suppresses the variegation of the short scutellar bristle phenotype characteristic for T(2;3)Sb^V adults leading to a significantly higher proportion of short (stubble) bristles than in T(2;3)Sb^V alone.

(Gandhi et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Gas41^f05565 has majority die during first instar larval stage phenotype, enhanceable by armi^72.1

(Gandhi et al., 2015)

Gas41^f05565 has melanotic necrosis | adult stage phenotype, enhanceable by armi^72.1

(Gandhi et al., 2015)

Gas41^f05565 has majority die during first instar larval stage phenotype, enhanceable by Dcr-1^Q1147X

(Gandhi et al., 2015)

Gas41^f05565 has melanotic necrosis | adult stage phenotype, enhanceable by Dcr-1^Q1147X

(Gandhi et al., 2015)

Suppressor of

Statement

Reference

Gas41[+]/Gas41^f05565 is a suppressor | partially of abnormal eye color phenotype of w^RNAi.GMR.cGa

(Gandhi et al., 2015)

Gas41[+]/Gas41^f05565 is a suppressor | partially of visible | adult stage phenotype of w^RNAi.GMR.cGa

(Gandhi et al., 2015)

Gas41^f05565/Gas41^NP2248 is a suppressor | partially of abnormal eye color phenotype of w^RNAi.GMR.cGa

(Gandhi et al., 2015)

Gas41^f05565/Gas41^NP2248 is a suppressor | partially of visible | adult stage phenotype of w^RNAi.GMR.cGa

(Gandhi et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Gas41^f05565 has scutum phenotype, enhanceable by armi^72.1

(Gandhi et al., 2015)

Gas41^f05565 has scutellum phenotype, enhanceable by armi^72.1

(Gandhi et al., 2015)

Gas41^f05565 has scutum phenotype, enhanceable by Dcr-1^Q1147X

(Gandhi et al., 2015)

Gas41^f05565 has scutellum phenotype, enhanceable by Dcr-1^Q1147X

(Gandhi et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The mortality of Gas41^f05565 homozygotes as well as the necrotic patches (on scutum, notum and scutellum) observed in the surviving adults is further enhanced by combination with either armi^72.1 or Dcr-1^Q1147X.

Combination of w^{dsRNA.GMR.cGa} with Gas41^f05565 or Gas41^NP2248 individually in heterozygous or together in transheterozygous state, significantly ameliorates the loss of pigmentation in the adult eye induced by the w^{dsRNA.GMR.cGa} RNAi.

(Gandhi et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

18886