FB2024_03 , released June 25, 2024
Allele: Dmel\GluRIIC2
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General Information
Symbol
Dmel\GluRIIC2
Species
D. melanogaster
Name
FlyBase ID
FBal0160413
Feature type
allele
Associated gene
Dmel\GluRIIC
Associated Insertion(s)
Carried in Construct
Also Known As
DGluRIII2, GluRIII2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Marrus et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Leaky expression of GluRIICUAS.cMa (without a GAL4 driver) under the control of Scer\GAL4G14 in a GluRIIC2/Df(2L)ast1 mutant background results in a significant reduction in bouton number at muscles 6/7 and 4 NMJs compared to controls.

      (Sulkowski et al., 2014)

      GluRIIC2 synaptic mutants exhibit wild-type bouton structure.

      (Dickman et al., 2006)

      The ionophoretic response to glutamate at the neuromuscular junction is approximately 13-fold less than that of wild-type larvae in GluRIIC2/Df(2L)ast1 larvae carrying GluRIICScer\UAS.cMa in the absence of an Scer\GAL4 driver. In addition, these mutant animals show a 2.5-fold reduction in mean miniature excitatory junctional potential (mEJP) amplitude and a 14.4-fold reduction in mEJP frequency compared to wild type. At low calcium levels (0.47mM), there is no difference between the excitatory junctional current (EJC) amplitude of the mutant synapse and of the wild-type synapse. However, at high external calcium levels (1.5mM), the mutant synapses generate an EJC only 1/5 the size of the wild-type EJC.

      (Marrus and DiAntonio, 2004)

      Hemizygotes and GluRIIC1/GluRIIC2 animals are embryonic lethal. Late stage embryos are grossly normal but are paralysed and fail to hatch.

      (Marrus et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      GluRIIC2 is rescued by GluRIIC+tg

      (Marrus et al., 2004)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DGluRIII2
      (Dickman, 2006, Dickman et al., 2006, Marrus and DiAntonio, 2004)
      GluRIIC2
      GluRIII2
      (Sulkowski et al., 2014, Marrus et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)