FB2024_03 , released June 25, 2024
Allele: Dmel\BursZ4410
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General Information
Symbol
Dmel\BursZ4410
Species
D. melanogaster
Name
FlyBase ID
FBal0159432
Feature type
allele
Associated gene
Dmel\Burs
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dewey et al., 2004)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A. Mutations is at the splice acceptor site for the second exon. This likely prevents normal splicing, leading to read-through of the first intron, which would result in premature termination due to the presence of two consecutive stop codons (the resulting protein product is predicted to contain the signal sequence and only 12 additional amino acids).

(Dewey et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,769,744..21,769,744 [+]
Nucleotide change:

G21769744A

Reported nucleotide change:

G?A

Comment:

Mutation at the splice acceptor for the second exon; leads to read-through of first intron and early translation termination.

(Dewey et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The programmed cell death which is seen in wild-type wings during wing maturation after eclosion still occurs in bursZ5569/bursZ4410 flies.

      (Natzle et al., 2008)

      Mutants have wing spreading and sclerotization defects.

      (Dewey et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      4410
      (McNabb and Truman, 2006)
      BursZ4410
      bursZ4410
      (Natzle et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)