FB2024_03 , released June 25, 2024
Allele: Dmel\su(Hw)e04061
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General Information
Symbol
Dmel\su(Hw)e04061
Species
D. melanogaster
Name
FlyBase ID
FBal0158596
Feature type
allele
Associated gene
Dmel\su(Hw)
Associated Insertion(s)
PBac{RB}su(Hw)e04061
Carried in Construct
Also Known As
su(Hw)Pb
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{RB}su(Hw)e04061
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      All su(Hw)2/su(Hw)e04061 mid-oogenesis egg chambers exhibit apoptosis, which is only rarely observed in controls.

      3 days-old su(Hw)2/su(Hw)e04061 testes show disorganized individualization complexes, a bulge at the end of the testes, reduced sperm production and small seminal vesicles.

      (Glenn and Geyer, 2019)

      su(Hw)e04061/Df(3R)su(Hw)-A1933 transheterozygotes are viable but female sterile and also lack the gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes).

      (Baxley et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      su(Hw)e04061/su(Hw)2 has male semi-fertile | progressive phenotype, enhanceable by HIPP1ΔDsR/HIPP1Δ37

      (Glenn and Geyer, 2019)
      NOT suppressed by
      Statement
      Reference

      su(Hw)e04061/su(Hw)2 has female sterile phenotype, non-suppressible by HIPP1ΔDsR/HIPP1Δ37

      (Glenn and Geyer, 2019)
      Enhancer of
      Statement
      Reference

      su(Hw)e04061 is an enhancer of decreased body size | larval stage phenotype of HIPP1UAS.mCh, Scer\GAL4Act.PU

      (Stow et al., 2022)
      Other
      Statement
      Reference

      HIPP1Δ37, su(Hw)[+]/su(Hw)e04061 has male fertile phenotype

      (Glenn and Geyer, 2019)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mid-oogenesis apoptosis observed in su(Hw)2/su(Hw)e04061 transheterozygotes is not suppressed by HIPP1Δ37/HIPP1ΔDsR.

      HIPP1Δ37/+, su(Hw)e04061/+ males are fertile.

      (Glenn and Geyer, 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The female sterility phenotype and the loss of gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes) caused by su(Hw)e04061 is not complemented by su(Hw)A2663 and partially complemented with either su(Hw)A460 or su(Hw)M393 (both a separation-of-function allele), which restore either the female fertility or the insulator function, respectively.

      (Baxley et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (9)