FlyBase Allele Report: Dmel\tkv[QD.UAS.cUa]

General Information

Symbol

Dmel\tkv^QD.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0158563

Feature type

allele

Associated gene

Dmel\tkv

Associated Insertion(s)

Carried in Construct

P{UAS-tkv.QD.U}

Also Known As

UAS-tkv^QD, tkv^QD, UAS-TkvQD

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Gilboa and Lehmann, 2004)

Progenitor genotype

Carried in construct

P{UAS-tkv.QD.U}

Cytology

Description

UAS regulatory sequences drive expression of a constitutively active form of tkv.

(Gilboa and Lehmann, 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

tkv

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | oogenesis, with Scer\GAL4^nanos.PU

(Zhao et al., 2022)

Phenotype Manifest In

dorsal appendage, with Scer\GAL4^CY2

(Yakoby et al., 2008)

egg operculum, with Scer\GAL4^CY2

(Yakoby et al., 2008)

embryonic/larval tracheal dorsal trunk, with Scer\GAL4^btl.PS

(Iordanou et al., 2014)

female germline stem cell | increased number, with Scer\GAL4^nanos.PU

(Zhao et al., 2022)

Detailed Description

Statement

Reference

Scer\GAL4^btl.PS-mediated expression of tkv^{QD.Scer\UAS.cUa} results in defective tracheal dorsal trunk formation.

(Iordanou et al., 2014)

Expression of tkv^QD.Scer\UAS under the control of Scer\GAL4^CY2 results in the loss of dorsal appendages and expansion of the operculum in the eggshell.

(Yakoby et al., 2008)

The precocious differentiation of primordial germ cells which is seen in nos¹⁸/Df(3R)Dl-FX3 larval ovaries is partially suppressed by expression of tkv^QD.Scer\UAS under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

(Gilboa and Lehmann, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^nanos.PU, tkv^QD.UAS.cUa has increased cell number | oogenesis phenotype, non-enhanceable by Scer\GAL4^nanos.PU/dind^{RNAi.UAS.RNAi}

(Zhao et al., 2022)

NOT suppressed by

Statement

Reference

Scer\GAL4^nanos.PU, tkv^QD.UAS.cUa has increased cell number | oogenesis phenotype, non-suppressible by Scer\GAL4^nanos.PU/dind^{RNAi.UAS.RNAi}

(Zhao et al., 2022)

Suppressor of

Statement

Reference

tkv^QD.UAS.cUa, Scer\GAL4^ap.PU is a suppressor of increased cell death phenotype of Gli^UAS.cSa, Scer\GAL4^ap.PU

(Sharifkhodaei et al., 2016)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^nanos.PU, tkv^QD.UAS.cUa has female germline stem cell | increased number phenotype, non-enhanceable by Scer\GAL4^nanos.PU/dind^{RNAi.UAS.RNAi}

(Zhao et al., 2022)

NOT suppressed by

Statement

Reference

Scer\GAL4^nanos.PU, tkv^QD.UAS.cUa has female germline stem cell | increased number phenotype, non-suppressible by Scer\GAL4^nanos.PU/dind^{RNAi.UAS.RNAi}

(Zhao et al., 2022)

Scer\GAL4^btl.PS, tkv^QD.UAS.cUa has embryonic/larval tracheal dorsal trunk phenotype, non-suppressible by Scer\GAL4^btl.PS/exp^B.UAS.Tag:HA

(Iordanou et al., 2014)

NOT Enhancer of

Statement

Reference

Scer\GAL4^btl.PS/tkv^QD.UAS.cUa is a non-enhancer of embryonic/larval tracheal lateral trunk phenotype of exp¹³⁵

(Iordanou et al., 2014)

Scer\GAL4^btl.PS/tkv^QD.UAS.cUa is a non-enhancer of embryonic/larval ganglionic tracheal branch phenotype of exp¹³⁵

(Iordanou et al., 2014)

Suppressor of

Statement

Reference

tkv^QD.UAS.cUa, Scer\GAL4^ap.PU is a suppressor of wing disc phenotype of Gli^UAS.cSa, Scer\GAL4^ap.PU

(Sharifkhodaei et al., 2016)

Scer\GAL4^btl.PS/tkv^QD.UAS.cUa is a suppressor of dorsal tracheal branch primordium phenotype of btl⁹⁵

(Myat et al., 2005)

Scer\GAL4^{VP16.nanos.UTR}/tkv^QD.UAS.cUa is a suppressor | partially of germline cell | female | larval stage phenotype of nanos¹⁸/Df(3R)Delta-FX3

(Gilboa and Lehmann, 2004)

Scer\GAL4^{VP16.nanos.UTR}/tkv^QD.UAS.cUa is a suppressor | partially of germline cyst | ectopic phenotype of nanos¹⁸/Df(3R)Delta-FX3

(Gilboa and Lehmann, 2004)

NOT Suppressor of

Statement

Reference

Scer\GAL4^btl.PS/tkv^QD.UAS.cUa is a non-suppressor of embryonic/larval tracheal lateral trunk phenotype of exp¹³⁵

(Iordanou et al., 2014)

Scer\GAL4^btl.PS/tkv^QD.UAS.cUa is a non-suppressor of embryonic/larval ganglionic tracheal branch phenotype of exp¹³⁵

(Iordanou et al., 2014)

Scer\GAL4^btl.PS/tkv^QD.UAS.cUa is a non-suppressor of tracheal lateral trunk anterior branch primordium phenotype of btl⁹⁵

(Myat et al., 2005)

Other

Statement

Reference

Scer\GAL4^btl.PS, btl⁹⁵, tkv^QD.UAS.cUa has tracheal dorsal trunk primordium phenotype

(Myat et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of tkv^{QD.Scer\UAS.cUa} suppresses the migration of wing disc cells expressing Gli^Scer\UAS.cSa under the control of Scer\GAL4^ap.PU into the non-expressing side of the disc.

(Sharifkhodaei et al., 2016)

Scer\GAL4^btl.PS-mediated expression of tkv^{QD.Scer\UAS.cUa} has no effect on the tracheal cyst phenotype of exp¹³⁵ embryos.

(Iordanou et al., 2014)

Expression of tkv^QD.Scer\UAS, under the control of Scer\GAL4^btl.PS, partially rescues the dorsal branch tracheal phenotype of btl⁹⁵ mutant embryos but fails to rescue the lateral trunk defect and causes defects in dorsal trunk formation.

(Myat et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

tkv^{QD.Scer\UAS.cUa}

tkv^QD.Scer\UAS

tkv^QD.UAS.cUa

tkv^QD

(Zhao et al., 2022, Lopes and Casares, 2015)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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