Amino acid replacement: M255V.
UAS regulatory sequences drive expression of a M255V variant of the 541 amino acid isoform of Psn cloned into P{Express-UAS}. The M255V change mimics the M239V change in humans (revision of data reported in FBrf0178861).
A20433789G
M255V | Psn-PA; M255V | Psn-PB; M255V | Psn-PC; M255V | Psn-PD; M255V | Psn-PE
Analogous M239V mutation in human PSEN2 implicated in Alzheimer's disease 4; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.