FlyBase Allele Report: Dmel\Vang[UAS.mGFP6]

General Information

Symbol

Dmel\Vang^UAS.mGFP6

Species

D. melanogaster

Name

FlyBase ID

FBal0155718

Feature type

allele

Associated gene

Dmel\Vang

Associated Insertion(s)

Carried in Construct

P{UAS-Vang::GFP}

Key Links

Transgenic product class

wild_type

(Bellaiche et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Bellaiche et al., 2004)

Mutagen

in vitro construct

(Bellaiche et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-Vang::GFP}

Cytology

Description

UAS sequences control the expression of mGFP6 fused in frame to the first codon of Vang.

(Bellaiche et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Vang

Tagged with

mGFP6

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

(Gombos et al., 2015)

Phenotype Manifest In

adult mushroom body beta-lobe, with Scer\GAL4^ey-OK107

(Gombos et al., 2015)

mushroom body medial lobe, with Scer\GAL4^ey-OK107

(Gombos et al., 2015)

Detailed Description

Statement

Reference

When Vang^{Scer\UAS.T:Avic\GFP-m6} is expressed in the mushroom body under the control of Scer\GAL4^ey-OK107 the β lobe axons fail to terminate properly at the CNS midline and display medial lobe fusion phenotype.

(Gombos et al., 2015)

The orientation of division of sensory organ precursor cells in the developing nota of Vang^{Scer\UAS.T:Avic\GFP-m6}; Scer\GAL4^neur-P72 pupae is normal.

(Bellaiche et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ey-OK107, Vang^UAS.mGFP6 has abnormal neuroanatomy phenotype, suppressible by DAAM^Ex1

(Gombos et al., 2015)

Scer\GAL4^ey-OK107, Vang^UAS.mGFP6 has abnormal neuroanatomy phenotype, suppressible | partially by dsh¹

(Gombos et al., 2015)

Scer\GAL4^ey-OK107, Vang^UAS.mGFP6 has abnormal neuroanatomy phenotype, suppressible | partially by Rac1^J11

(Gombos et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ey-OK107, Vang^UAS.mGFP6 has adult mushroom body beta-lobe phenotype, suppressible by DAAM^Ex1

(Gombos et al., 2015)

Scer\GAL4^ey-OK107, Vang^UAS.mGFP6 has mushroom body medial lobe phenotype, suppressible by DAAM^Ex1

(Gombos et al., 2015)

Scer\GAL4^ey-OK107, Vang^UAS.mGFP6 has mushroom body medial lobe phenotype, suppressible | partially by dsh¹

(Gombos et al., 2015)

Scer\GAL4^ey-OK107, Vang^UAS.mGFP6 has mushroom body medial lobe phenotype, suppressible | partially by Rac1^J11

(Gombos et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Hemizygous DAAM^Ex1 suppresses the β lobe axon overextension and medial lobe fusion phenotype seen when Vang^{Scer\UAS.T:Avic\GFP-m6} is expressed in male flies under the control of Scer\GAL4^ey-OK107.

Hemizygous dsh¹ partially suppresses the medial lobe fusion phenotype seen when Vang^{Scer\UAS.T:Avic\GFP-m6} is expressed in male flies under the control of Scer\GAL4^ey-OK107.

Hemizygous Rac1^J11 partially suppresses the medial lobe fusion phenotype seen when Vang^{Scer\UAS.T:Avic\GFP-m6} is expressed in male flies under the control of Scer\GAL4^ey-OK107.

(Gombos et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^neur-P72/Vang^UAS.mGFP6 rescues Vang^stbm-6

(Bellaiche et al., 2004)

Comments

Vang^{Scer\UAS.T:Avic\GFP-m6}; Scer\GAL4^neur-P72 rescues oriented cell division in the pupal notum of Vang^stbm-6 mutant animals.

(Bellaiche et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Vang^{Scer\UAS.T:Avic\GFP-m6}

Vang^UAS.mGFP6

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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