FB2024_03 , released June 25, 2024
Allele: Dmel\fz::smoSSF.UAS
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General Information
Symbol
Dmel\fz::smoSSF.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0155266
Feature type
allele
Associated gene
fz::smo
Associated Insertion(s)
Carried in Construct
P{UAS-fz::smo.SSF}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hooper, 2003)
Progenitor genotype
Carried in construct
P{UAS-fz::smo.SSF}
Cytology
Description

UASt regulatory sequences drive expression of a chimeric construct consisting of the smo extracellular cysteine-rich domain and transmembrane domains and the fz cytoplasmic tail. The chimeric protein is tagged with Tag:MYC immediately following the smo putative signal sequence and with Tag:HA immediately before the fz stop codon.

(Hooper, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
fz::smo
Tagged with
Tag:HA
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of two copies of fz::smoSSF.Scer\UAS under the control of hemizygous Scer\GAL4Bx-MS1096 results in a subtle narrowing of the L3/4 interval in the wing.

      (Hooper, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4Bx-MS1096, fz::smoSSF.UAS, smo[+]/smo3 has 1st posterior cell phenotype, suppressible by Scer\GAL4Bx-MS1096, fz::smoSSF.UAS

      (Hooper, 2003)
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4Bx-MS1096, fz::smoSSF.UAS has 1st posterior cell phenotype, non-suppressible by cos+t6.1

      (Hooper, 2003)
      Suppressor of
      Statement
      Reference

      Scer\GAL4Bx-MS1096, fz::smoSSF.UAS is a suppressor of 1st posterior cell phenotype of Scer\GAL4Bx-MS1096, fz::smoSSF.UAS, smo[+]/smo3

      (Hooper, 2003)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of high levels of fz::smoSSF.Scer\UAS under the control of Scer\GAL4Bx-MS1096 in a smo3/+ background results in a reduction in the spacing between the 3rd and 4th wing vein. Co-expression of fuScer\UAS.cAb only weakly suppresses the reduction in spacing between the 3rd and 4th wing vein seen in flies expressing high levels of fz::smoSSF.Scer\UAS under the control of Scer\GAL4Bx-MS1096 in a smo3/+ background. The reduction in spacing between the 3rd and 4th wing vein seen in flies expressing high levels of fz::smoSSF.Scer\UAS under the control of Scer\GAL4Bx-MS1096 in a smo3/+ background is suppressed by co-expression of smoScer\UAS.cHa.T:Hsap\MYC. The reduction in spacing between the 3rd and 4th wing vein seen in flies expressing high levels of fz::smoSSF.Scer\UAS under the control of Scer\GAL4Bx-MS1096 is not suppressed by cos+t6.1.

      (Hooper, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fz::smoSSF.Scer\UAS
      fz::smoSSF.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)