Imprecise excision of the P{EP}EP2141 element, deletes the entire homer coding region.
bifR47/homerLL17 mutants exhibit severe defects in the anchoring of osk RNA and proteins at the posterior of the developing oocyte. The F-actin cytoskeleton in these mutants are indistinguishable from wild-type. Polarity of microtubules appears normal and the cytoskeleton-dependant cytoplasmic streaming occurs normally. Treating these oocytes with an actin depolymerisation drug does not exacerbate the phenotype. When bifR47 single mutant oocytes are treated with an actin depolymerisation drug osk anchoring is not affected.