FB2024_03 , released June 25, 2024
Allele: Dmel\vrsZ2566
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General Information
Symbol
Dmel\vrsZ2566
Species
D. melanogaster
Name
FlyBase ID
FBal0154987
Feature type
allele
Associated gene
Dmel\vrs
Associated Insertion(s)
Carried in Construct
Also Known As
mcl(3)Z2566
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wakimoto et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: D2V.

(Binder et al., 2017)

Nucleotide substitution: A89T.

(Binder et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:12,447,741..12,447,741 [+]
Nucleotide change:

A12447741T

Reported nucleotide change:

A89T

Amino acid change:

D2V | vrs-PA

Reported amino acid change:

D2V

(Binder et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      vrsZ2566 does not complement Df(3)Desat11573-C'1, Df(3R)ED5610 or Df(3R)Exel7316.

      Early embryos (mitotic cycles 1-3) derived from vrsZ2566 homozygous fathers and control mothers show asynchrony in nuclear cycles and an array of chromosome defects, including chromosome loss, micronuclei at interphase, isolated chromosomes at metaphase, lagging chromosomes and bridges at anaphase and telophase, as compared to controls. A significant proportion of embryos derived from vrsZ2566/Df(3)Desat11573-C'1 transheterozygous fathers and control mothers also show loss of chromosomes, as compared to heterozygous fathers.

      (Binder et al., 2017)

      Homozygous males are fertile, but their progeny show paternal chromosome loss (loss rate of chromosome 4 is 8%). The timing of the chromosome loss has not been determined but there is no cytological evidence for chromosome loss during spermatogenesis.

      (Wakimoto et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      vrsZ2566 is rescued by vrsEGFP

      (Binder et al., 2017)
      Comments

      Two paternal copies of vrsEGFP rescue the loss of chromosomes observed in the embryos derived from vrsZ2566/Df(3)Desat11573-C'1 transheterozygous fathers and control mothers.

      (Binder et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mcl(3)Z2566
      (Binder et al., 2017, Wakimoto et al., 2004)
      mcl(3)Z2566Z2566
      vrsZ2566
      (Binder et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)