FB2024_03 , released June 25, 2024
Allele: Dmel\smoC.UAS.Tag:MYC,Tag:Myr(v-Src)
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General Information
Symbol
Dmel\smoC.UAS.Tag:MYC,Tag:Myr(v-Src)
Species
D. melanogaster
Name
FlyBase ID
FBal0154573
Feature type
allele
Associated gene
Dmel\smo
Associated Insertion(s)
Carried in Construct
P{UAS-smo.C.MycMyr}
Key Links
Transgenic product class
inframe_deletion
(Hooper, 2003)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Hooper, 2003)
Mutagen
in vitro construct
(Hooper, 2003, Ogden et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-smo.C.MycMyr}
Cytology
Description

UASt regulatory sequences drive expression of the cytoplasmic tail of smo tagged at the N-terminal end with Tag:MYC and a myristoylation tag (Tag:Myr(v-Src)).

(Hooper, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
smo
Tagged with
Tag:MYC
Tag:Myr(v-Src)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of two copies of smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4 under the control of hemizygous Scer\GAL4Bx-MS1096 results in ectopic venation in the wing with no effect on the L3/4 intervein. Expression of two copies of smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4 under the control of hemizygous Scer\GAL4Bx-MS1096 results in strong ectopic venation in the wing and variable overgrowth of the costa. Wing vein L3 expands anteriorly to fill the L2/3 intervein and the L3/4 intervein is reduced. The ectopic venation and L3/4 narrowing caused by expression of smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4 under the control of Scer\GAL4Bx-MS1096 is suppressed by co-expression of smoScer\UAS.cHa.T:Hsap\MYC.

      (Hooper, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4Bx-MS1096, smoC.UAS.Tag:MYC,Tag:Myr(v-Src) has visible phenotype, suppressible by cos+t6.1

      (Hooper, 2003)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The overgrowth of the costa, ectopic venation and narrowing of the L3/4 intervein caused by expression of smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4 under the control of hemizygous Scer\GAL4Bx-MS1096 are suppressed by cos+t6.1. Co-expression of ptcEP941 completely suppresses the ectopic venation and costal overgrowth caused by expression of smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4 under the control of hemizygous Scer\GAL4Bx-MS1096 and instead reduces the wing to a tiny scrap. The ectopic venation and costal overgrowth caused by expression of smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4 under the control of hemizygous Scer\GAL4Bx-MS1096 in a smo3/+ background is enhanced by co-expression of fuScer\UAS.cAb, while the L3/4 narrowing is suppressed.

      (Hooper, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4prd.RG1/smoC.UAS.Tag:MYC,Tag:Myr(v-Src) fails to rescue smo1/smo3

      (Hooper, 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in plasmid "pUAS-myc-myr-SmoC" and transfected into clone 8 cells.

      (Ogden et al., 2003)

      Carried in plasmid "pUAS-smoC" and transfected into Clone-8 cells.

      (Ogden et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr-v-Src
      smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4
      smoC.UAS.Tag:MYC,Tag:Myr(v-Src)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)