FB2024_03 , released June 25, 2024
Allele: Dmel\tauUASp.mGFP6
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General Information
Symbol
Dmel\tauUASp.mGFP6
Species
D. melanogaster
Name
FlyBase ID
FBal0151384
Feature type
allele
Associated gene
Dmel\tau
Associated Insertion(s)
Carried in Construct
P{UASp-tau.A:mGFP6}
Also Known As
UAS-dTau, UAS-tau-GFP
Key Links
Transgenic product class
wild_type
(Doerflinger et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Doerflinger et al., 2003)
Mutagen
in vitro construct
(Doerflinger et al., 2003)
Progenitor genotype
Carried in construct
P{UASp-tau.A:mGFP6}
Cytology
Description

UASp regulatory sequences drive expression of the full length tau-A open reading frame, tagged at the C-terminal end with mGFP6.

(Doerflinger et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
tau
Tagged with
mGFP6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4BG380 in larval neuromuscular junctions does not lead to specific accumulation of a subset of synaptic cargo in axons, as compared to controls.

      (Barber et al., 2017)

      Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 has no effect on oocyte nucleus localisation.

      (Tian and Deng, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The penetrance of the oocyte mislocalisation phenotype seen in egg chambers of females expressing par-1Scer\UAS.ΔSP.T:Avic\GFP under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 is reduced by co-expression of tauScer\UAS.P\T.T:Avic\GFP-m6 (from 96% to 33%).

      (Tian and Deng, 2009)

      Flies that express tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4elav-C155 show a 25% reduction in the size of vacuoles that develop in the mechanosensory neuropil compared to futscholk1 flies that do not express the transgene.

      (Bettencourt da Cruz et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      tauUASp.mGFP6/Scer\GAL4GMR.PU rescues tauGD8682

      (Bolkan and Kretzschmar, 2014)

      Scer\GAL4Appl.G1a/tauUASp.mGFP6 rescues tauGD8682

      (Bolkan and Kretzschmar, 2014)

      tauUASp.mGFP6/Scer\GAL4VP16.mat.αTub67C rescues tauMR22

      (Tian and Deng, 2009)
      Comments

      Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 significantly rescues the retinal degeneration seen in one week old flies expressing tauGD8682 under the control of Scer\GAL4GMR.PU.

      Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 partially rescues the semi-lethality seen when tauGD8682 is expressed under the control of Scer\GAL4Appl.G1a.

      (Bolkan and Kretzschmar, 2014)

      The oocyte nucleus mislocalisation defect seen in tauMR22 germline clones is rescued by expression of tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

      (Tian and Deng, 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tauGFP
      (Barber et al., 2017)
      tauScer\UAS.P\T.T:Avic\GFP-m6
      tauUASp.mGFP6
      Name Synonyms
      Secondary FlyBase IDs
        References (9)