FlyBase Allele Report: Dmel\Mmp1[f1.UAS]

General Information

Symbol

Dmel\Mmp1^f1.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0150755

Feature type

allele

Associated gene

Dmel\Mmp1

Associated Insertion(s)

Carried in Construct

P{UAS-Mmp1.f1}

Also Known As

UAS-Mmp1, UAS-Mmp1.F1

Key Links

Transgenic product class

cDNA

(Page-McCaw et al., 2003)

wild_type

(Page-McCaw et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Page-McCaw et al., 2003)

wild_type

(Page-McCaw et al., 2003)

Mutagen

in vitro construct

(Page-McCaw et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-Mmp1.f1}

Cytology

Description

Expression of Mmp1 isoform f1 cDNA, is under the control of UASt sequences.

(Page-McCaw et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mmp1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates epilepsy

modeled by eas²

(Cho et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PU

(Miller et al., 2008)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^repo.PU

(Miller et al., 2008)

lethal - all die during embryonic stage, with Scer\GAL4^Cg.PA

(Schmidt et al., 2011)

some die during embryonic stage, with Scer\GAL4^Cg.PA

(Schmidt et al., 2011)

Phenotype Manifest In

adult thoracic sensillum, with Scer\GAL4^dpp.PH

(Glasheen et al., 2009)

chaeta, with Scer\GAL4^dpp.PH

(Glasheen et al., 2009)

egg chamber, with Scer\GAL4^GMR47A04

(Deady et al., 2015)

follicle cell, with Scer\GAL4^GMR47A04

(Deady et al., 2015)

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^elav.PU

(Miller et al., 2008)

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^repo.PU

(Miller et al., 2008)

larval segmental nerve branch SNa of A1-7, with Scer\GAL4^elav.PU

(Miller et al., 2008)

larval segmental nerve branch SNa of A1-7, with Scer\GAL4^repo.PU

(Miller et al., 2008)

macrochaeta & adult thorax, with Scer\GAL4^dpp.PH

(Page-McCaw et al., 2003)

Detailed Description

Statement

Reference

The expression of Mmp1^f1.UAS under the control of Scer\GAL4^bbg-C96 (and Dicer-2 for a more efficient RNAi) induces notches along the wing margin.

(Mok and Choi, 2021)

In females with expression of Mmp1^f1.Scer\UAS driven by Scer\GAL4^GMR47A04, some mature eggs rupture and most released eggs retain some follicle cells.

(Deady et al., 2015)

Expression of Mmp1^f1.Scer\UAS under the control of Scer\GAL4^dpp.PH results in short stubby, easily broken bristles on the thorax of adult flies.

(Glasheen et al., 2009)

Scer\GAL4^elav.PU-mediated expression of Mmp1^f1.Scer\UAS interferes with embryonic motor axon guidance: ISNb and SNa morphology/path-finding is disrupted, and exhibit phenotypes consistent with increased motor axon fasciculation. Expression via Scer\GAL4^repo.PU has similar effects but with lower penetrance; the number and position of repo-positive glia are unaffected. Mis-expression of Mmp1^f1.Scer\UAS in mesoderm or in hemocytes does not result in motor axon phenotypes.

(Miller et al., 2008)

Expression of Mmp1^f1.Scer\UAS in border cells, driven by Scer\GAL4^slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte.

(Medioni and Noselli, 2005)

Mmp1^f1.Scer\UAS; Scer\GAL4^GMR.PF flies have normal eyes. The thoracic macrochaetae of Mmp1^f1.Scer\UAS; Scer\GAL4^dpp.PH flies tend to break of shortly after eclosion.

(Page-McCaw et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Mmp1^f1.UAS, Mnat9^KK109382, Scer\GAL4^bbg-C96 has lethal phenotype

(Mok and Choi, 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Mmp1^f1.UAS, Scer\GAL4^dpp.PH has macrochaeta & thorax phenotype, suppressible by Timp^UAS.cPa, Scer\GAL4^dpp.PH

(Page-McCaw et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The thoracic macrochaeta phenotype due to Mmp1^f1.Scer\UAS; Scer\GAL4^dpp.PH is suppressed by the presence of one copy of Timp^Scer\UAS.cPa.

(Page-McCaw et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Mmp1^f1.UAS is rescued by Mmp1^{Pro-pex.f1.UAS}/Scer\GAL4^dpp.PH

(Glasheen et al., 2009)

Comments

Expression of Mmp1^{Pro-pex.f1.Scer\UAS} suppresses the bristle phenotype observed in flies expressing Mmp1^f1.Scer\UAS under the control of Scer\GAL4^dpp.PH.

(Glasheen et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

58700

w^*; P{UAS-Mmp1.f1}2

58701

w^*; P{UAS-Mmp1.f1}3

Notes on Origin

Discoverer