FlyBase Allele Report: Dmel\AP-2α[ear4]

General Information

Symbol

Dmel\AP-2α^ear4

Species

D. melanogaster

Name

FlyBase ID

FBal0148525

Feature type

allele

Associated gene

Dmel\AP-2α

Associated Insertion(s)

Carried in Construct

Also Known As

ada^ear4

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Berdnik et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: R841term.

(Berdnik et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:409,809..409,809 [-]

Nucleotide change:

C409809T

Reported nucleotide change:

C?T

Amino acid change:

R841term | AP-2alpha-PA; R853term | AP-2alpha-PB

Reported amino acid change:

R841term

(Berdnik et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

external sensory organ precursor cell IIa | ectopic | somatic clone

(Berdnik et al., 2002)

external sensory organ precursor cell IIb | somatic clone

(Berdnik et al., 2002)

macrochaeta | somatic clone

(Berdnik et al., 2002)

microchaeta | somatic clone

(Berdnik et al., 2002)

tormogen cell | ectopic | somatic clone

(Berdnik et al., 2002)

Detailed Description

Statement

Reference

Centrosome asymmetry during cytokinesis in mutant pI (sensory organ precursor) cells in the notum is identical to that seen in wild-type pI cells.

(Jauffred et al., 2013)

Within α-Adaptin^ear4 pIIa-pIIb cells, an apical actin-rich structure (ARS) is formed normally.

(Rajan et al., 2009)

In somatic clones of α-Adaptin^ear4 in the head, most bristles are transformed to have 2-4 socket cells and no shaft. In α-Adaptin^ear4 somatic clones in the head, 92% of the macrochaetae show cell fate transformations of either pIIb into pIIa or hair to socket. Similar defects, although at a lower frequency, occur in microchaetae in these clones.

(Berdnik et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

AP-2α^ear4 has tormogen cell | ectopic | somatic clone phenotype, non-suppressible by numb^hs.PU

(Berdnik et al., 2002)

AP-2α^ear4 has macrochaeta | somatic clone phenotype, non-suppressible by numb^hs.PU

(Berdnik et al., 2002)

NOT Suppressor of

Statement

Reference

AP-2α^ear4 is a non-suppressor of macrochaeta | heat sensitive phenotype of N^l1N-ts1

(Berdnik et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The bristle transformations seen in α-Adaptin^ear4 clones are unaffected by the presence numb^hs.PU together with heat shock (2x45 minute 37^oC heat shocks separated by 30 minutes, at 16-18 hours APF). Macrochaetae in somatic clones of α-Adaptin^ear4 in a N^l1N-ts1 background at 29^oC exhibit a phenotype typical of N (bristle loss), rather than that seen in α-Adaptin^ear4 somatic clones in a wild-type background (transformation to socket cells).

(Berdnik et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

AP-2α⁰⁶⁶⁹⁴

(Berdnik et al., 2002)

Fails to complement

AP-2α³

(Berdnik et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

AP-2α^ear4

(Lin et al., 2015)

Ada^ear4

(Rajan et al., 2009)

ada^ear04

(Hutterer and Knoblich, 2005)

ada^ear4

(Sallé et al., 2017, Couturier et al., 2013, Jauffred et al., 2013, Berdnik et al., 2002)

α-Adaptin^ear4

α-ada^ear4

(Tong et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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