FB2024_03 , released June 25, 2024
Allele: Dmel\Lis-1UAS.cLa
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General Information
Symbol
Dmel\Lis-1UAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Liu
FlyBase ID
FBal0147812
Feature type
allele
Associated gene
Dmel\Lis-1
Associated Insertion(s)
Carried in Construct
P{UAS-Lis-1.L}
Also Known As
UAS-Lis1
Key Links
Transgenic product class
cDNA
(Liu et al., 2000)
wild_type
(Liu et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Liu et al., 2000)
wild_type
(Liu et al., 2000)
Mutagen
in vitro construct
(Liu et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-Lis-1.L}
Cytology
Description

UASt regulatory sequences drive expression of a Lis-1 cDNA.

(Liu et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Lis-1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Lis-1Scer\UAS.cLa driven by Scer\GAL4ppk.PU does not significantly affect dendrite branch number or position in ddaC neurons of third instar larvae compared to controls.

      (Arthur et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Lis-1UAS.cLa/Scer\GAL4ppk.PU is a suppressor of dendrite | third instar larval stage phenotype of nudE39A

      (Arthur et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Lis-1Scer\UAS.cLa driven by Scer\GAL4ppk.PU significantly suppresses decreases in dendrite length, branch number and distribution seen in nudE39A/nudE39A third instar larval class IV da neurons.

      (Arthur et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Lis-1UAS.cLa/Scer\GAL4shot-OK307 rescues Lis-1k11702/Lis-1G10.14

      (Kudumala et al., 2017)

      Scer\GAL4ey-OK107/Lis-1UAS.cLa rescues Lis-1G10.14

      (Liu et al., 2000)
      Partially rescues

      Scer\GAL4GMR91H05/Lis-1UAS.cLa partially rescues Lis-1k11702/Lis-1G10.14

      (Kudumala et al., 2017)
      Comments

      The expression of Lis-1Scer\UAS.cLa is able to rescue the Lis-1k11702/Lis-1G10.14 giant fiber anatomical defects (full rescue when driven by either Scer\GAL4shot-OK307 or Scer\GAL4GMR91H05) and electrophysiological defects (full rescue when driven by Scer\GAL4shot-OK307; partial rescue when driven by Scer\GAL4GMR91H05).

      (Kudumala et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Lis-1Scer\UAS.cLa
      Lis-1UAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Liu
      (Liu et al., 2000)
      Secondary FlyBase IDs
        References (3)