FB2024_03 , released June 25, 2024
Allele: Dmel\PgkKG07478
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General Information
Symbol
Dmel\PgkKG07478
Species
D. melanogaster
Name
FlyBase ID
FBal0147685
Feature type
allele
Associated gene
Dmel\Pgk
Associated Insertion(s)
P{SUPor-P}PgkKG07478
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}PgkKG07478
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  muscular dystrophy
      modeled by DgO86
      (Kucherenko et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      FlyBase curator comment: Interactions with Dg[086] and/or Dg[323] were detected in a Dg[086]/+ or Dg[323]/+ background which exhibits no obvious changes in muscle morphology. Nonetheless, these interactions have been captured as 'modifier' ('exacerbates') annotations here to best capture the experimental finding and the authors' intention.

      (Kucherenko et al., 2011)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Dg[+]/DgO86, PgkKG07478 has abnormal locomotor behavior | temperature conditional phenotype

      (Kucherenko et al., 2011)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Dg[+]/DgO86, PgkKG07478 has indirect flight muscle cell | nutrition conditional phenotype

      (Kucherenko et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pgk Dys double heterozygous flies (PgkKG07478/Df(3R)Exel6184) do not exhibit indirect flight muscle degeneration when raised on either normal or sugar-free food.

      PgkKG07478 DgO86 double heterozygous flies exhibit indirect flight muscle degeneration when raised on normal food, but this degeneration is not seen when flies are raised on sugar-free food. In contrast to either heterozygote alone, temperature -sensitive mobility defects are observed in the double heterozygotes.

      PgkKG07478/+ mutant flies do not exhibit temperature-induced mobility defects.

      (Kucherenko et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PgkKG07478
      (Kucherenko et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)