FB2024_03 , released June 25, 2024
Allele: Dmel\klgruslan
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General Information
Symbol
Dmel\klgruslan
Species
D. melanogaster
Name
FlyBase ID
FBal0147086
Feature type
allele
Associated gene
Dmel\klg
Associated Insertion(s)
P{GAL4}klgruslan
Carried in Construct
Also Known As
klgrus, D0417, ruslan
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Dubnau et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{GAL4}klgruslan
Cytology
Description

The klgruslan mutation results from an insertion of a P{GAL4} transposon in the first exon (+97 bp), oriented in the opposite direction to klg transcription.

(Matsuno et al., 2009)
Allele components
Component
Use(s)
Inserted element
P{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      1-day memory after spaced training is disrupted in homozygous klgruslan and heterozygous klgruslan/klgE226 flies.

      (Matsuno et al., 2009)

      Homozygous klgruslan mutants show increased sensitivity to ethanol vapor compared with controls. klgruslan mutant flies also show reduced rapid tolerance to ethanol. Whereas control flies exhibit a reduced behavioural response following pre-exposure to intoxicating levels of ethanol, klgruslan mutant flies exposed to either ethanol or air produce a similar response. Chronic tolerance is also reduced; unlike in controls no change in behavioural response is seen following overnight pre-exposure to a low concentration of ethanol (never reaching intoxicating levels).

      (Berger et al., 2008)

      In memory tests, mutants perform at 91% of wild-type after a single training session, at 31% after spaced training.

      (Dubnau et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      klgruslan is a suppressor of abnormal memory | heat sensitive phenotype of NHsp70Bb.PL

      (Matsuno et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The enhancement of long-term memory by NHsp70Bb.PL over-expression is suppressed in klgruslan flies.

      (Matsuno et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Etymology: Given the name "ruslan", after one of Pavlov's dogs.

      (Dubnau et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (6)