FB2024_03 , released June 25, 2024
Allele: Dmel\Fmr12
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General Information
Symbol
Dmel\Fmr12
Species
D. melanogaster
Name
FlyBase ID
FBal0137501
Feature type
allele
Associated gene
Dmel\Fmr1
Associated Insertion(s)
Carried in Construct
Also Known As
dfmr12
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Dockendorff et al., 2002)
Progenitor genotype
Fmr1EP3517
(Dockendorff et al., 2002)
Cytology
Description

Excision of P{EP}Fmr1EP3517 and deletion of distal flanking DNA including the entire Fmr1 ORF.

(Dockendorff et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At day 5 post-eclosion, Fmr12 mutant brains retain midline PDF tritocerebral (PDF-TRI) neurons that are not present in age-matched wild-type.

      (Gatto and Broadie, 2011)

      The number of mature type 1b boutons is significantly increased in the Fmr1Δ50M null synapse and the number of immature satellite boutons is similarly elevated. The increase in number of mature boutons and the accumulation of satellite neurons are both rescued when the larvae are fed >20uM minocycline.

      (Siller and Broadie, 2011)

      Flies show no visible phenotypic abnormalities.

      (Dockendorff et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (8)