FlyBase Allele Report: Dmel\Wnt2[unspecified]

General Information

Symbol

Dmel\Wnt2^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0135760

Feature type

allele

Associated gene

Dmel\Wnt2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile

(Llimargas and Lawrence, 2001)

partially lethal

(Llimargas and Lawrence, 2001)

Phenotype Manifest In

direct flight muscle cell

(Kozopas and Nusse, 2002)

Detailed Description

Statement

Reference

Mutant adults have normal looking indirect flight muscle, but exhibit a phenotype in the direct flight muscle.

(Kozopas and Nusse, 2002)

Wnt2^unspecified embryos and larvae have normal trachea.

(Llimargas and Lawrence, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by wntD^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by Wnt6^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by Wnt6^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, suppressible | partially by wntD^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

NOT suppressed by

Statement

Reference

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt10^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt10^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt4^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt4^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt5^UAS.cSa/Scer\GAL4^btl.PS

(Llimargas and Lawrence, 2001)

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype, non-suppressible by Wnt5^UAS.cSa/Scer\GAL4^wg.PM

(Llimargas and Lawrence, 2001)

Other

Statement

Reference

Wnt2^unspecified, wg^l-17 has tracheal dorsal trunk primordium phenotype

(Llimargas and Lawrence, 2001)

Df(2L)RF, Wnt2^unspecified has tracheal dorsal trunk primordium phenotype

(Llimargas and Lawrence, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

In wg^l-17 Wnt2^unspecified double mutants in 40-45% of hemisegments, the dorsal trunk is completely missing, and in the remaining hemisegments only some reduced and thin dorsal trunk forms. Wnt2^unspecified Df(2L)RF embryos lack the dorsal trunk of the tracheal system in nearly all hemisegments. Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS can substantially rescue the dorsal trunk which is missing in wg^l-17 Wnt2^unspecified double mutant embryos. Expression of Wnt2^Scer\UAS.cSa under the control of Scer\GAL4^wg.PM in a wg^l-17 Wnt2^unspecified double mutant background rescues some dorsal trunk in the trachea. However when Wnt2^Scer\UAS.cSa is expressed under the control of Scer\GAL4^btl.PS there is strong rescue, and more dorsal trunk is made. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^wg.PM in a wg^l-17 Wnt2^unspecified double mutant background rescues some dorsal trunk in the trachea. However when wg^Scer\UAS.cLa is expressed under the control of Scer\GAL4^btl.PS there is strong rescue, and more dorsal trunk is made.

(Llimargas and Lawrence, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Wnt2^unspecified

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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