FB2024_03 , released June 25, 2024
Allele: Dmel\easunspecified
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General Information
Symbol
Dmel\easunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0128043
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
alaunspecified
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
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    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Disease
    Evidence
    References
    model of  epilepsy
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Mutants lack alpha and alpha' lobes of the mushroom bodies. The more intensively flies are trained, the less they remember; they show almost non memory 5 hours after spaced conditioning. Anasthesia resistant consolidated memory seems to be erased during a long term memory-specific training protocols.

    Mutants are bang-sensitive, with a recovery period of 52 +/- 10 seconds and a refractory period of 510 +/- 30 seconds.

    Mutant flies show a reduced seizure threshold (of 4.5 +/- 0.2 V) compared to wild type in response to high-frequency electrical stimulation.

    1-hour, 3-hour, 24-hour (spaced training) and 24-hour (massed training) memory are normal in mutant flies. 3-hour memory is not reduced in mutant flies lacking either α α' or β β' lobes of the mushroom body. Long term memory (24-hour spaced training) is normal in the flies which have β β' lobes, but is completely abolished in flies which lack the α α' lobes (the long term memory defect is not caused by the fused β β' lobe defect which may be seen in these flies). 24-hour (massed training) memory is not reduced in flies lacking the α α' lobes.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
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    Reference
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    Genetic Interactions
    Statement
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    Xenogenetic Interactions
    Statement
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    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    easunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (5)