FB2024_03 , released June 25, 2024
Allele: Dmel\hth1-487.VP16.UAS
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General Information
Symbol
Dmel\hth1-487.VP16.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0127214
Feature type
allele
Associated gene
Dmel\hth
Associated Insertion(s)
Carried in Construct
P{UAS-VP16-hth.1-487}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Inbal et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-VP16-hth.1-487}
Cytology
Description

UASt sequences drive expression of full length hth fused to the VP16 activation domain.

(Inbal et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
hth
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of hth1-487.Scer\UAS.T:Hsim\VP16 under the control of Scer\GAL4dpp.blk1 results in extremely reduced or missing eyes. The proximal portion of the antenna appears normal, but the arista is abnormal, with the phenotype varying from fusion of the base or loss of the spines to its complete absence. The proximal segments of the leg (coxa, trochanter and proximal femur) are unaffected but the distal structures of the leg are deformed and condensed together. In most cases, all distal elements, including the claws, can be detected. The sex combs can be seen on the first leg of males, but the organisation of the teeth is abnormal. Birfurcations are also seen in the distal parts of the leg.

      (Inbal et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      hth1-487.VP16.UAS/Scer\GAL4Kr.PM partially rescues hth64-1

      (Inbal et al., 2001)
      Comments

      The localisation and number of LCh5 neurons is rescued in abdominal segments A1-4 in hth64-1 embryos expressing hth1-487.Scer\UAS.T:Hsim\VP16 under the control of Scer\GAL4Kr.PM.

      (Inbal et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hth1-487.Scer\UAS.T:Hsim\VP16
      hth1-487.VP16.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)