FlyBase Allele Report: Dmel\caps[ED.UAS]

General Information

Symbol

Dmel\caps^ED.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0125101

Feature type

allele

Associated gene

Dmel\caps

Associated Insertion(s)

Carried in Construct

P{UAS-caps.ED}

Key Links

Transgenic product class

inframe_deletion

(Taniguchi et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Taniguchi et al., 2000)

Mutagen

in vitro construct

(Taniguchi et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-caps.ED}

Cytology

Description

UASt regulatory sequences drive expression of caps lacking the region extending from the second LRR domain to the amino acid just preceding the transmembrane domain.

(Taniguchi et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

caps

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Ectopic expression of caps^ED.Scer\UAS, a construct lacking the extracellular part, in the developing eye, under the control of Scer\GAL4^GMR.PF, does not induce any mistargeting of R7 axons, indicating that the ectodomain is essential for caps function.

Expression of caps^ED.Scer\UAS under the control of Scer\GAL4^sev.PM181 does not induce any mistargeting of R7 axons, indicating that the ectodomain is essential for caps function.

(Berger-Müller et al., 2013)

Embryos that express caps^ED.Scer\UAS under the control of Scer\GAL4^twi.PG show normal development of the tracheal system.

(Krause et al., 2006)

Third instar larvae expressing caps^ED.Scer\UAS under the control of Scer\GAL4^elav.PLu at 29^oC show no defects in the trajectory of the motorneurons that innervate muscle 12. Expression of caps^ED.Scer\UAS under the control of Scer\GAL4^how-24B does not result in an increased frequency of the terminals of motorneurons that normally innervate muscle 12 forming ectopic synapses on muscle 13.

(Taniguchi et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^twi.PG/caps^ED.UAS is a suppressor | partially of tracheal dorsal trunk primordium phenotype of trn^28.4

(Krause et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of caps^ED.Scer\UAS under the control of Scer\GAL4^twi.PG in trn^28.4 embryos rescues the dorsal trunk defects in 47% of cases.

(Krause et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

caps^ED.Scer\UAS

caps^ED.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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