FB2024_03 , released June 25, 2024
Allele: Dmel\cdiR47
Open Close
General Information
Symbol
Dmel\cdiR47
Species
D. melanogaster
Name
FlyBase ID
FBal0123023
Feature type
allele
Associated gene
Dmel\cdi
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Sese et al., 2006)
Mutagen
Delta2-3 transposase
(Matthews and Crews, 1999)
Progenitor genotype
P{FZ}cdi242
(Matthews and Crews, 1999)
P{lacZ}cdi87
(Matthews and Crews, 1999)
Caused by aberration
Df(3R)cdiR47
Cytology
Description

2.077bp deletion that removes the first exon of cdi and removes the mRpL55 gene.

(Sese et al., 2006)

Imprecise excision of the P-element resulting in a 2.1kb deletion which removes cdi sequences. The open reading frame of the neighbouring ATPsyn-d gene is unaffected by this deletion.

(Matthews and Crews, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      F-actin distribution is irregular, granulated and disorganised in homozygous Df(3R)cdiR47 clones in the eye disc in which mRpL55 function has been restored by expression of mRpL55Scer\UAS.cSa under the control of Scer\GAL4GMR.PU. These defects are less evident in mosaic ommatidia composed of both mutant and wild-type cells.

      (Sese et al., 2006)

      Mutants have an affected nervous system.

      (Kraut et al., 2001)

      Although the reading frame of the neighbouring ATPsyn-d gene is unaffected in the "cdiR47" mutant chromosome, it remains possible that its function could be affected, thus it is unclear whether the lethality of the "cdiR47" mutant chromosome is due to an affect on cdi or ATPsyn-d.

      (Matthews and Crews, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      cdiR47/cdi[+] is an enhancer of male semi-sterile phenotype of Rac1J11

      (Raymond et al., 2004)
      Other
      Statement
      Reference

      Rac2Δ, cdiR47/cdi[+] has male fertile phenotype

      (Raymond et al., 2004)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Rac1J11, cdiR47/cdi[+] has testis phenotype

      (Raymond et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      74% of Rac1J11 cdiR47/Rac1J11 males are sterile in individual crosses with females. The males have an abnormal accumulation of dense material in the distal part of the testis.

      (Raymond et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Selected as: flies which have lost the ry+ eye colour marker of the P-element progenitor (P{lacZ}cdi87 or P{FZ}cdi242).

      (Matthews and Crews, 1999)
      Comments
      Comments

      "FBti0009052 == P{lacZ}cdi87" was stated as tentative. "FBti0003444 == P{FZ}cdi242" was stated as tentative.

      (Matthews and Crews, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cdiR47
      (Christensen et al., 2009.2.28, Sese et al., 2006, Raymond et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)