FlyBase Allele Report: Dmel\Delta[UAS.cLa]

General Information

Symbol

Dmel\Delta^UAS.cLa

Species

D. melanogaster

Name

FlyBase ID

FBal0122287

Feature type

allele

Associated gene

Dmel\Delta

Associated Insertion(s)

Carried in Construct

P{UAS-Delta.L}

Also Known As

UAS-Dl

Key Links

Transgenic product class

wild_type

(Lee et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Lee et al., 2000)

Mutagen

in vitro construct

(Li and Baker, 2001, Lee et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Delta.L}

Cytology

Description

Dl with modified UTR sequences is driven by UAS sequences.

(Lee et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Delta

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Li et al., 2003)

sensory mother cell | ectopic | somatic clone | third instar larval stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Pitsouli and Delidakis, 2005)

Detailed Description

Statement

Reference

Dl^Scer\UAS.cLa third instar nota clones (under the regulation of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) usually contain two to four ectopic sensory organ precursors, with some clones appearing wild-type.

(Pitsouli and Delidakis, 2005)

When Dl^Scer\UAS.cLa is driven by Scer\GAL4^GMR.PF, mutant adults have abnormal, rough eyes. However R8 organisation in the imaginal disc appears normal.

(Li et al., 2003)

When Dl^Scer\UAS.cLa is driven by Scer\GAL4^h-1J3 the neural development in the eye disc begins normally in the posterior of the disc but becomes progressively disorganised more anteriorly as differentiation accelerates.

(Li and Baker, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Scer\GAL4^pros.PMG, Delta^UAS.cLa, neur^UAS.cPa is a non-suppressor of abnormal neuroanatomy phenotype of spdo^G104

(Babaoglan et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Delta^UAS.cLa has sensory mother cell | third instar larval stage | ectopic phenotype, enhanceable by Scer\GAL4^{VP16.mat.αTub67C}/fng^UAS.cKa

(Pitsouli and Delidakis, 2005)

Delta^UAS.cLa has sensory mother cell | third instar larval stage | ectopic phenotype, enhanceable by Ser^UAS.cGa/Scer\GAL4^{VP16.mat.αTub67C}

(Pitsouli and Delidakis, 2005)

Enhancer of

Statement

Reference

Delta^UAS.cLa/Scer\GAL4^GMR.PF is an enhancer of photoreceptor cell R8 phenotype of N^spl-1

(Li et al., 2003)

Suppressor of

Statement

Reference

Scer\GAL4^twi.PG, Delta^UAS.cLa, neur^UAS.cPa is a suppressor of embryonic pericardial cell phenotype of spdo^G104

(Babaoglan et al., 2009)

NOT Suppressor of

Statement

Reference

Scer\GAL4^pros.PMG, Delta^UAS.cLa, neur^UAS.cPa is a non-suppressor of dMP2 neuron | ectopic phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^pros.PMG, Delta^UAS.cLa, neur^UAS.cPa is a non-suppressor of vMP2 neuron phenotype of spdo^G104

(Babaoglan et al., 2009)

Scer\GAL4^pros.PMG, Delta^UAS.cLa, neur^UAS.cPa is a non-suppressor of embryonic pericardial cell phenotype of spdo^G104

(Babaoglan et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of neur^Scer\UAS.cPa and Dl^Scer\UAS.cLa under the control of Scer\GAL4^twi.PG has no effect on eve-positive pericardial cell numbers.

Expression of neur^Scer\UAS.cPa and Dl^Scer\UAS.cLa under the control of Scer\GAL4^twi.PG in a spdo^G104 mutant background does not alter the number of eve-positive pericardial cells compared to spdo^G104 mutant embryos.

Co-expression of neur^Scer\UAS.cPa and Dl^Scer\UAS.cLa under the control of Scer\GAL4^twi.PG in a spdo^G104 mutant background partially restore svp-positive pericardial cell development by promoting more asymmetric divisions of progenitor cells.

(Babaoglan et al., 2009)

Dl^Scer\UAS.cLa, Ser^Scer\UAS.cGa double-mutant third instar nota clones (under the regulation of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) typically contain ten or more ectopic sensory organ precursors. Dl^Scer\UAS.cLa, fng^Scer\UAS.cKa double-mutant third instar nota clones (under the regulation of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}) display a significantly higher number of sensory organ precursors per cluster than single mutants. Addition of the Dl^Scer\UAS.cLa transgene, to Dl^RevF10 Ser^RX106 double mutant third instar nota clones, under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}, partially rescues the ectopic SOP phenotype, with approximately 8.5% of SOP positions exhibiting between four and eight SOPs.

(Pitsouli and Delidakis, 2005)

When Dl^Scer\UAS.cLa is driven by Scer\GAL4^GMR.PF in a N^spl-1 background photoreceptor R8 differentiation is greatly reduced.

(Li et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Delta^UAS.cLa

Dl^Scer\UAS.cLa

Dl^UAS.cLa

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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