FlyBase Allele Report: Dmel\Fas2[rd1]

General Information

Symbol

Dmel\Fas2^rd1

Species

D. melanogaster

Name

FlyBase ID

FBal0122123

Feature type

allele

Associated gene

Dmel\Fas2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning

(Cheng et al., 2001)

abnormal memory

(Cheng et al., 2001, Cheng et al., 2001)

visible | male

(Adam et al., 2003)

Phenotype Manifest In

border follicle cell

(Szafranski and Goode, 2004)

male genitalia

(Adam et al., 2003)

Detailed Description

Statement

Reference

Delamination and migration of border follicle cells are both accelerated in Fas2^rd1 homozygotes.

(Szafranski and Goode, 2004)

About 20% of mutant adult males show genitalia rotation defects.

(Adam et al., 2003)

Mutants show significantly lower memory than control flies at multiple times after olfactory classical conditioning.

(Cheng et al., 2001)

Mushroom bodies from mutant animals do not have any detectable phenotype. In odour avoidance tests, mutant flies avoidance the aversive odours of octanol and benzaldehyde to the same degree as wild-type controls. Odour response after preshock is also wild-type. Mutant flies' ability to perceive and avoid electrified grids also appears to be normal. In odour learning tests, mutant flies exhibit relatively poor performance compared to wild-type flies when tested 3 minutes after odour conditioning. When trained with a short program schedule, mutants perform poorly relative to wild-type, but after normalisation, memory is seen to decay at an identical rate. Memory retrieval also appear to be wild-type. The defect appears to be in memory formation. When tested on an inebriometer, mutants show an increased ethanol sensitivity.

(Cheng et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Fas2^rd1 is rescued by Fas2^UAS.cLa/Scer\GAL4^BA3

(Szafranski and Goode, 2004)

Partially rescued by

Fas2^rd1 is partially rescued by Fas2^UAS.cLa/Scer\GAL4^slbo.2.6

(Szafranski and Goode, 2004)

Fas2^rd1 is partially rescued by Fas2^hs.PC

(Cheng et al., 2001)

Comments

The migration phenotypes of border follicle cells in Fas2^rd1 homozygotes are rescued by Fas2^Scer\UAS.cLa; Scer\GAL4^BA3. When Scer\GAL4^slbo.2.6 is used instead, the migration rate of the border follicle cells is rescued, but delamination is still delayed, and the border follicle cells lose their polarity.

(Szafranski and Goode, 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Fas2^rd1

fasII^rd1

(Cheng et al., 2001, Cheng et al., 2001, Cheng et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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