FB2024_03 , released June 25, 2024
Allele: Dmel\neurRING.UAS
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General Information
Symbol
Dmel\neurRING.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0121664
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt sequences drive expression of a fragment containing amino acids 691-754 of neur.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When a single copy of neurRING.Scer\UAS is driven by Scer\GAL4sca-537.4, viability is poor, in spite of this the effect on patterning is minimal, typically leading to the loss of only one or two dorsocentral macrochaetes. Multiple copies of neurRING.Scer\UAS yield a dramatic balding phenotype in the rare flies that survive to late pharate adult stage. Misexpression of neurRING.Scer\UAS when driven by Scer\GAL4Bx-MS1096 leads to an extreme disruption in the development and patterning of all cell types in the notum. Many sensory organs are missing and overall polarity is strongly affected. In addition development of the epidermal cells are also clearly disrupted, as large regions are devoid of the hairs normally produced by the epidermis. When neurRING.Scer\UAS is driven by Scer\GAL4Bx-MS1096, a severe decrease in wing size is seen resulting in strongly curved wings. The campaniform sensillae normally seen on wing vein L3 appear to be relatively normal.

Flies expressing neurRING.Scer\UAS under the control of Scer\GAL4GMR.PF, display a small eye phenotype with apparent tufting and a high degree of ommatidial pitting and scarring. Eye discs misexpressing one or three copies of neurRING.Scer\UAS under the control of Scer\GAL4GMR.PF display mild to severe derangement of patterning in the posterior of the eye disc.

neurRING.Scer\UAS; Scer\GAL4GMR.PF flies have small eyes with severely disrupted ommatidial architecture.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Scer\GAL4GMR.PF, neurRING.UAS has visible phenotype, suppressible | partially by effs1782/eff[+]

Phenotype Manifest In
Suppressed by
Statement
Reference

Scer\GAL4GMR.PF, neurRING.UAS has eye phenotype, suppressible | partially by effs1782/eff[+]

Additional Comments
Genetic Interactions
Statement
Reference

The eyes of neurRING.Scer\UAS; Scer\GAL4GMR.PF flies are increased in size by heterozygosity for effs1782.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
neurRING.Scer\UAS
neurRING.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)