FB2024_03 , released June 25, 2024
Allele: Dmel\rempA1
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General Information
Symbol
Dmel\rempA1
Species
D. melanogaster
Name
FlyBase ID
FBal0121565
Feature type
allele
Associated gene
Dmel\rempA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: G1712A.

    (Lee et al., 2008)

    Amino acid replacement: W465term.

    (Lee et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:557,178..557,178 [-]
    Nucleotide change:

    G557178A

    Reported nucleotide change:

    G1712A

    Amino acid change:

    W465term | rempA-PB; W420term | rempA-PC

    Reported amino acid change:

    W465term

    (Lee et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        adult antennal nerve

        (Eberl et al., 2000)

        Johnston organ neuron

        (Lee et al., 2018)

        leg

        (Eberl et al., 2000)

        scolopidial cilium & Johnston's organ

        (Lee et al., 2008)

        scolopidial cilium & pentascolopidial chordotonal organ

        (Lee et al., 2008)

        wing

        (Eberl et al., 2000)
        Detailed Description
        Statement
        Reference

        rempA1 mutants show no ciliary transport (anterograde or retrograde) in Johnston's organ chordotonal neurons, as compared to controls.

        (Lee et al., 2018)

        Hemizygous adults lack antennal sound-evoked potentials.

        Cilia in the scolopidia of the pentascolopidial chordotonal organ end in the scolopale in homozygous larvae, at about half wild-type length (the cilia extend through the scolopale and into the distal extracellular caps in wild-type scolopidia).

        The cilia in the antennal chordotonal organ are truncated in mutant adults and the ciliary dilation, which is normally present at about two-thirds the length of the cilium, proximal to the dendritic cap, is absent.

        (Lee et al., 2008)

        Flies are uncoordinated showing frequent leg crossing and wings held up or out. Walking and righting ability is impaired. Spontaneous or induced (by light or mechanical stimuli) activity is vigorous. The sound evoked response (measured via the antennal nerve) is eliminated. ERGs are normal.

        (Eberl et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        rempAk12913

        (Lee et al., 2008)

        rempAk12913

        (Lee et al., 2008)

        rempA21Ci-1

        (Lee et al., 2008)
        Rescued by

        rempA1 is rescued by rempAVenus

        (Lee et al., 2008)
        Comments

        rempAk12913 and rempA21Ci-1 each fail to complement the behavioural and viability defects of rempA1.

        (Lee et al., 2008)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        rempA1
        (Kwon et al., 2020, Lee et al., 2018, Park et al., 2013, Lee et al., 2008, Lee et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)