FB2024_03 , released June 25, 2024
Allele: Dmel\robo29
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General Information
Symbol
Dmel\robo29
Species
D. melanogaster
Name
FlyBase ID
FBal0121554
Feature type
allele
Associated gene
Dmel\robo2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Rajagopalan et al., 2000)
Mutagen
ethyl methanesulfonate
(Rajagopalan et al., 2000)
Progenitor genotype
robo2EP2582
(Rajagopalan et al., 2000)
Cytology
Description

Amino acid replacement: S120F (revision of data in FBrf0132258). Amino acid replacements are relative to the 1406 amino acid residue predicted protein.

(Dickson, 2001.3.14)

Amino acid replacement: S177F. See Dickson, 2001.3.14, personal communication for subsequent revision of this information.

(Rajagopalan et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:1,395,929..1,395,929 [-]
Nucleotide change:

C1395929T

Amino acid change:

S177F | robo2-PA; S177F | robo2-PB

Reported amino acid change:

S177F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Rajagopalan et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The adult sLNv neurons of robo29/robo24 transheterozygotes show several morphological defects of variable penetrance, including axon projection defects and mis-placed cell body, as compared to controls; however, the few mutant axons that do reach the calyx display normal length of the terminal branches.

      (Oliva et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      learobo2-9
      robo29
      (Oliva et al., 2016, Dickson, 2001.3.14, Rajagopalan et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)