FlyBase Allele Report: Dmel\swa[TN62]

General Information

Symbol

Dmel\swa^TN62

Species

D. melanogaster

Name

FlyBase ID

FBal0121510

Feature type

allele

Associated gene

Dmel\swa

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q461term.

(Schnorrer et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:6,363,944..6,363,944 [-]

Nucleotide change:

C6363944T

Amino acid change:

Q462term | swa-PA

Reported amino acid change:

Q461term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Schnorrer et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/first instar larval cuticle | maternal effect (with Df(1)JF5)

(Pokrywka et al., 2004)

Detailed Description

Statement

Reference

Embryos derived from swa^TN62/Df(1)JF5 females mated to wild-type males often show cuticle defects, ranging from embryos without cuticle and lacking any sign of development (38%), through embryos with a reduction in the number of abdominal segments to embryos that have 8 abdominal segments, with normal or nearly normal abdominal morphology. The most commonly represented cuticular class is embryos that have 4-6 abdominal segments, with the arrangement of segments usually abberant, with segments often fused (40%).

(Pokrywka et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

swa^TN62/swa[+] is a non-suppressor of female sterile | semidominant phenotype of αTub67C³

(Pokrywka et al., 2004)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

swa^TN62/swa[+] is a non-suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of αTub67C³

(Pokrywka et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 36.1% of embryos derived from swa^TN62/+;αTub67C³/+ females hatch to apparently normal embryos, compared to approximately 44.8% of embryos derived from αTub67C³/+ females. Approximately 48.0% of embryos derived from swa^TN62/+;67C³/+ females arrest development before cuticle formation, compared to approximately 37.2% of embryos derived from αTub67C³/+ females. Approximately 15.8% of embryos derived from female swa^TN62/+;αTub67C³/+ flies arrest development after cuticle formation but before hatching, compared to approximately 18% in embryos derived from αTub67C³/+ females.

(Pokrywka et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

TN62

(Pokrywka et al., 2000)

swa^TN62

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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