FlyBase Allele Report: Hsap\PSEN1[loopA.UAS]

General Information

Symbol

Hsap\PSEN1^loopA.UAS

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Noll

FlyBase ID

FBal0120809

Feature type

allele

Associated gene

Hsap\PSEN1

Associated Insertion(s)

Carried in Construct

P{UAS-hPS1.loopA}

Key Links

Transgenic product class

inframe_deletion

(Noll et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Noll et al., 2000)

Mutagen

in vitro construct

(Noll et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-hPS1.loopA}

Cytology

Description

UASt sequences drive expression of amino acids 263-407 of Hsap\PSEN1.

(Noll et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\PSEN1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Noll et al., 2000)

some die during embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Noll et al., 2000)

Phenotype Manifest In

embryonic/first instar larval cuticle, with Scer\GAL4^{VP16.mat.αTub67C}

(Noll et al., 2000)

embryonic dorsal epidermis, with Scer\GAL4^{VP16.mat.αTub67C}

(Noll et al., 2000)

embryonic head, with Scer\GAL4^{VP16.mat.αTub67C}

(Noll et al., 2000)

Detailed Description

Statement

Reference

Expression of Hsap\PSEN1^loopA.UAS under the control of Scer\GAL4^Appl.G1a does not lead to axonal blockages in third instar larval segmental nerves compared to controls.

(Banerjee et al., 2018)

When Hsap\PSEN1^{loopA.Scer\UAS} is driven by Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} in the embryo, most embryos die. Those that survive to develop more cuticular elements, phenotypes include loss of head structures, variable degrees of segmental fusion, and a dorsal open phenotype.

(Noll et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Hsap\PSEN1^loopA.UAS, Scer\GAL4^Appl.G1a is a non-enhancer of larval segmental nerve | third instar larval stage phenotype of Scer\GAL4^Appl.G1a, sgg^UAS.cBa

(Banerjee et al., 2018)

Hsap\PSEN1^loopA.UAS, Scer\GAL4^Appl.G1a is a non-enhancer of axon | third instar larval stage phenotype of Scer\GAL4^Appl.G1a, sgg^UAS.cBa

(Banerjee et al., 2018)

Suppressor of

Statement

Reference

Hsap\PSEN1^loopA.UAS, Scer\GAL4^Appl.G1a is a suppressor of larval segmental nerve | third instar larval stage phenotype of Scer\GAL4^Appl.G1a, sgg^S9A.UAS

(Banerjee et al., 2018)

Hsap\PSEN1^loopA.UAS, Scer\GAL4^Appl.G1a is a suppressor of axon | third instar larval stage phenotype of Scer\GAL4^Appl.G1a, sgg^S9A.UAS

(Banerjee et al., 2018)

NOT Suppressor of

Statement

Reference

Hsap\PSEN1^loopA.UAS, Scer\GAL4^Appl.G1a is a non-suppressor of larval segmental nerve | third instar larval stage phenotype of Scer\GAL4^Appl.G1a, sgg^UAS.cBa

(Banerjee et al., 2018)

Hsap\PSEN1^loopA.UAS, Scer\GAL4^Appl.G1a is a non-suppressor of axon | third instar larval stage phenotype of Scer\GAL4^Appl.G1a, sgg^UAS.cBa

(Banerjee et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\PSEN1^{loopA.Scer\UAS}

Hsap\PSEN1^loopA.UAS

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Noll

(Noll et al., 2000)

Secondary FlyBase IDs

References (2)

Report Sections

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