FB2024_03 , released June 25, 2024
Allele: Dmel\Indy302
Open Close
General Information
Symbol
Dmel\Indy302
Species
D. melanogaster
Name
FlyBase ID
FBal0120790
Feature type
allele
Associated gene
Dmel\Indy
Associated Insertion(s)
P{lacW}Indy302
Carried in Construct
Also Known As
Indy302
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Rogina et al., 2000)
Progenitor genotype
Associated Insertion(s)
P{lacW}Indy302
Cytology
Description

P{lacW} insertion within 50bp of the putative transcriptional start site.

(Rogina et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous females and males do not show an extended lifespan (after correction for genetic and cytoplasmic background effects).

      (Toivonen et al., 2007)

      .Homozygous mutants are long lived, but have normal metabolic rates and flight velocity. Mutant flies have higher fecundity than wild-type early in life when fed on high quality food, also having a higher total life-time egg production. When on low-calorie food though fecundity is significantly decreased.

      (Marden et al., 2003)

      Heterozygotes show an increase in mean life-span to 69 days (compared to 37 days for controls) at 25oC, an extension in mean life-span of 87%. Extension of 1% maximal life-span is greater than 45%. At 18oC, the increase in mean life-span in mutants approaches 100% and the increase in 1% maximum life-span approaches 50% compared to controls. Heterozygous males and females are normal or superior in fertility and fecundity. Heterozygous females show the same early peak of egg laying and fertility as control females but sustain the ability to produce larger numbers of offspring for a longer period of time.

      (Rogina et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Indy302/Indy[+], Scer\GAL4DJ651 is a suppressor of short lived phenotype of Ctet\tetXTNT-LC.UAS, Scer\GAL4DJ651

      (Bauer et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced lifespan seen in males expressing Ctet\TeTxLCTNT.Scer\UAS under the control of Scer\GAL4DJ651 can be increased if the males also carry Indy302/+. Only a small increase in lifespan is seen in females expressing Ctet\TeTxLCTNT.Scer\UAS under the control of Scer\GAL4DJ651 and carrying Indy302/+.

      (Bauer et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference

      The reduced lifespan seen in males expressing Ctet\TeTxLCTNT.Scer\UAS under the control of Scer\GAL4DJ651 can be increased if the males also carry Indy302/+. The reduced lifespan seen in females expressing Ctet\TeTxLCTNT.Scer\UAS under the control of Scer\GAL4DJ651 is only slightly increased by Indy302 heterozygosity.

      (Bauer et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{lacW} element can revert the increased life-span phenotype.

      (Rogina et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Indy302
      (Wang et al., 2009, Rogina et al., 2000)
      Indy302
      (Jeong et al., 2021, Toivonen et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)