FlyBase Allele Report: Dmel\bab2[Ar07]

General Information

Symbol

Dmel\bab2^Ar07

Species

D. melanogaster

Name

FlyBase ID

FBal0120551

Feature type

allele

Associated gene

Dmel\bab2

Associated Insertion(s)

Carried in Construct

Also Known As

bab^AR07

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

Df(3L)bab^Ar07

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

leg

(Baanannou et al., 2013)

tarsal segment 4

(Baanannou et al., 2013)

tarsal segment 5

(Baanannou et al., 2013)

Detailed Description

Statement

Reference

Homozygous bab2^Ar07 mutant adults display shortened tarsi with segmental joint fusions, particularly the fully penetrant fusion of ts4-5.

(Baanannou et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

bab1^Ar07, bab2^Ar07/bab2^E4 has visible phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has abnormal body color | female phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has female semi-sterile phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07 has visible phenotype

(Chu et al., 2002)

bab1^Ar07, bab2^Ar07 has female sterile | recessive phenotype

(Couderc et al., 2002)

bab1^Ar07, bab2^Ar07 has visible | recessive phenotype

(Couderc et al., 2002, Kopp et al., 2000)

bab1^Ar07, bab2^Ar07/bab2[+] has visible | dominant | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07/bab2[+] has abnormal body color | dominant | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has abnormal body color | recessive phenotype

(Kopp et al., 2000)

bab1^Ar07/bab1[+], bab2^Ar07 has visible | dominant | female phenotype

(Kopp et al., 2000)

bab1^Ar07/bab1[+], bab2^Ar07 has abnormal body color | dominant | female phenotype

(Kopp et al., 2000)

Phenotype Manifest In

Other

Statement

Reference

bab1^Ar07, bab2^Ar07/bab2^E4 has sex comb | ectopic phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has tarsal segment 2 phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has tarsal segment 3 phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has ovary phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has tarsal segment 4 phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has egg phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has adult abdominal segment 5 | female phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has adult abdominal segment 6 | female phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07/bab2^E4 has pretarsus phenotype

(Bardot et al., 2002)

bab1^Ar07, bab2^Ar07 has tarsal segment & joint phenotype

(Chu et al., 2002)

bab1^Ar07, bab2^Ar07 has antennal segment & joint phenotype

(Chu et al., 2002)

bab1^Ar07, bab2^Ar07 has leg phenotype

(Couderc et al., 2002)

bab1^Ar07, bab2^Ar07 has ovary phenotype

(Couderc et al., 2002)

bab1^Ar07, bab2^Ar07 has adult cuticle & abdominal segment 6 | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has adult cuticle & abdominal segment 2 phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has adult cuticle & abdominal segment 3 phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has adult cuticle & abdominal segment 4 phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has adult cuticle & abdominal segment 5 phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has adult cuticle & abdominal segment 6 phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has adult cuticle & abdominal segment 7 phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has abdominal tergite 7 & trichome | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has abdominal sternite 7 & trichome | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has abdominal sternite 6 & macrochaeta | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07/bab2[+] has adult cuticle & abdominal segment 5 | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has abdominal sternite 7 & macrochaeta | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has hypogynial tooth | female phenotype

(Kopp et al., 2000)

bab1^Ar07/bab1[+], bab2^Ar07 has adult cuticle & abdominal segment 5 | female phenotype

(Kopp et al., 2000)

bab1^Ar07, bab2^Ar07 has abdominal sternite 6 | female phenotype

(Kopp et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

bab2^E4/Df(3L)bab^Ar07 flies have ectopic sex combs on tarsal segment 2 (7-8 bristles) and tarsal segment 3 (3-4 bristles) and show fusion of tarsal segments 4 and 5. Expression of bab1^Scer\UAS.cGa under the control of Scer\GAL4^bab1-Pgal4-2 partially rescues the mutant leg phenotypes of bab2^E4/Df(3L)bab^Ar07 flies; there is no sex comb on tarsal segment 3, tarsal segments 4 and 5 are separated by a well-defined joint but there is a small sex comb on tarsal segment 2 (1-2 bristles). Expression of bab2^4.Scer\UAS under the control of Scer\GAL4^bab1-Pgal4-2 fully rescues the mutant leg phenotypes of bab2^E4/Df(3L)bab^Ar07 flies; tarsal segments 2 and 3 do not have any sex combs and tarsal segments 4 and 5 are always properly separated. bab2^E4/Df(3L)bab^Ar07 females have ovaries of reduced size which contain only a few follicles with abnormal orientation. They are subfertile and lay very few eggs. These defects are partially rescued by bab1^Scer\UAS.cGa expressed under the control of Scer\GAL4^bab1-Pgal4-2 and are fully rescued by bab2^4.Scer\UAS expressed under the control of Scer\GAL4^bab1-Pgal4-2. bab2^E4/Df(3L)bab^Ar07 females show increased abdominal pigmentation; segments A5 and A6 are fully pigmented. This defect is not rescued by bab2^4.Scer\UAS expressed under the control of Scer\GAL4^bab1-Pgal4-2.

(Bardot et al., 2002)

Tarsal joints are fused or absent in Df(3L)bab^Ar07/Df(3L)bab^Ar07 animals and the a4/a5 and a5/arista joints are missing.

(Chu et al., 2002)

Homozygous Df(3L)bab^Ar07 females have a very strong mutant ovary phenotype; the ovaries are very small and no developing follicles are seen. Df(3L)bab^Ar07 homozygotes have a very strong mutant leg phenotype.

(Couderc et al., 2002)

Df(3L)bab^Ar07/+ females shows male-specific pigmentation of A5 and A6. Df(3L)bab^Ar07/Df(3L)bab^Ar07 males and females show ectopic pigmentation in A2-A7 tergites, A4-A7 sternites and occasionally in the A1 tergite. Df(3L)bab^Ar07/Df(3L)bab^Ar07 females expression of posterior morphological characters is increased: trichomes are absent from A7 tergite and sternite and the number of bristles on A6 and A7 sternites is reduced. A6 sternite bears some resemblance to the A6 sternite of males or the A7 sternite of females. The thorn bristles normally present in A8 are replaced by wavy bristles typical of the male A9 genital arch. The ectopic male pigmentation seen in Df(3L)bab^Ar07/+ females is suppressed by Df(3R)Ubx-RS4-8/+.

(Kopp et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bab2^Ar07 is rescued by bab2^+tBAC26B15

(Baanannou et al., 2013)

bab2^Ar07 is rescued by bab2^+mLAE

(Baanannou et al., 2013)

Not rescued by

bab2^Ar07 is not rescued by bab2^{BAC26B15.ΔLAE}

(Baanannou et al., 2013)

Comments

A single copy of bab2^+tBAC26B15 rescues the leg segmentation phenotype seen in bab2^Ar07 mutant flies.

A single copy of bab2^{BAC26B15.ΔLAE} fails to rescue the leg segmentation phenotype seen in bab2^Ar07 mutant flies.

Expression of bab2^+mLAE rescues the leg segmentation phenotype seen in bab2^Ar07 mutant flies.

(Baanannou et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37298

Df(3L)bab^Ar07, bab1^Ar07 bab2^Ar07/TM6B, Tb¹

Notes on Origin

Discoverer

F. Laski

(Kopp et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

bab-II^Ar07

bab2^Ar07

bab^AR07

(Baanannou et al., 2013, Lours et al., 2003, Bardot et al., 2002)

bab^ARO7

(Chu et al., 2002)

bab^Ar07

(Kopp et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (7)

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