FB2024_03 , released June 25, 2024
Allele: Dmel\png172
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General Information
Symbol
Dmel\png172
Species
D. melanogaster
Name
FlyBase ID
FBal0120388
Feature type
allele
Associated gene
Dmel\png
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Fenger et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: G157E. Mutation is in the DFG loop of the kinase domain.

(Fenger et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:1,357,064..1,357,064 [-]
Nucleotide change:

G1357064A

Amino acid change:

G157E | png-PA

Reported amino acid change:

G157E|FBrf0129806

Comment:

site of nucleic acid difference inferred by FlyBase based on stated amino acid change

(Fenger et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cells of mutant embryos contain assembled nuclear pore complexes and unusually large stacks of annulate lamellae with tightly packed annulate lamellae pore complexes.

      (Onischenko et al., 2005)

      Embryos derived from mutant females have a small number of apparently polyploid nuclei, rather than the normal, large number of diploid syncytial nuclei.

      (Tadros et al., 2003)

      Embryos derived from homozygous females show no evidence of mitosis, containing a single giant nucleus.

      (Fenger et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Swan B. Suter

      (Fenger et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      png172
      (Orr-Weaver, 2008.5.5, Onischenko et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)