FB2024_03 , released June 25, 2024
Allele: Dmel\trcL.UAS
Open Close
General Information
Symbol
Dmel\trcL.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0120298
Feature type
allele
Associated gene
Dmel\trc
Associated Insertion(s)
Carried in Construct
P{UAS-trc.L}
Key Links
Transgenic product class
wild_type
(Geng et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Geng et al., 2000)
Mutagen
in vitro construct
(Geng et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-trc.L}
Cytology
Description

UASt regulatory sequences drive expression of the trc-L isoform.

(Geng et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
trc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1RNAi.UAS.cYa
      (Wu et al., 2013)
      modeled by Pink1B9
      (Wu et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Coexpression of trcL.Scer\UAS with trcT453A.Scer\UAS, under the control of Scer\GAL4ap-md544, largely rescues the wing hair and bristle defects seen when trcT453A.Scer\UAS is expressed alone.

      (He et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of trcL.Scer\UAS suppresses the defects in flight ability caused by expression of Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW.

      The abnormal wing posture phenotype seen in flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is suppressed by co-expression of trcL.Scer\UAS.

      The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is suppressed by co-expression of trcL.Scer\UAS.

      The mitochondrial aggregation phenotype seen in the dopaminergic neurons of Pink1B9 flies is suppressed by expression of trcL.Scer\UAS under the control of Scer\GAL4ple.PF.

      The loss of dopaminergic neurons in the PPL1 cluster seen in Pink1B9 flies is suppressed by expression of trcL.Scer\UAS under the control of Scer\GAL4ple.PF.

      (Wu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      trcL.UAS/Scer\GAL4Act5C.PI partially rescues trcunspecified

      (Geng et al., 2000)
      Comments

      trcL.Scer\UAS rescues the wing hair and bristle phenotypes of trc null mutants when expressed under the control of Scer\GAL4Act5C.PI, with the animals dying as normal-looking pharate adults.

      (Geng et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      trcL.Scer\UAS
      trcL.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)