FB2024_03 , released June 25, 2024
Allele: Dmel\vnEPg35521
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General Information
Symbol
Dmel\vnEPg35521
Species
D. melanogaster
Name
FlyBase ID
FBal0120291
Feature type
allele
Associated gene
Dmel\vn
Associated Insertion(s)
P{EPg}vnEPg35521
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Fulga and Rorth, 2002, Duchek and Rorth, 2001, Duchek et al., 2001)
Progenitor genotype
Associated Insertion(s)
P{EPg}vnEPg35521
Cytology
Description

P{EPg} insertion in the 5' untranslated region. The P{EPg} element is inserted such that expression from the Scer\UAS sequences in the P{EPg} element drives expression of vn.

(Duchek and Rorth, 2001)
Allele components
Component
Use(s)
Inserted element
P{EPg}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Border cells in the ovaries of vnEPg35521; Scer\GAL4slbo.2.6 animals form significantly fewer long cellular extensions (20-40 μm) and intermediate cellular extensions (10-20 μm).

      (Fulga and Rorth, 2002)

      Border cell migration is affected when vnEPg35521 is expressed under the control of either Scer\GAL4slbo.2.6 or Scer\GAL4nos.UTR.T:Hsim\VP16 or both Scer\GAL4slbo.2.6 and Scer\GAL4nos.UTR.T:Hsim\VP16.

      (Duchek and Rorth, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      NOT Enhancer of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of vnEPg35521 and EgfrScer\UAS.T:Avic\GFP under the control of Scer\GAL4slbo.2.6 results in strong defects in border cell migration, with no migration being seen in approximately 80% of stage 10 egg chambers.

      (Inaki et al., 2012)

      The addition of PvrScer\UAS.cDa suppresses the effect of vnEPg35521 (driven by Scer\GAL4slbo.2.6). The addition of vnEPg35521 to PvrDN.Scer\UAS (driven by Scer\GAL4slbo.2.6) leads to a strong enhancement of the migration defect.

      (Duchek et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vnEPg35521
      Name Synonyms
      Secondary FlyBase IDs
        References (4)