FlyBase Allele Report: Dmel\EP639[EP639]

General Information

Symbol

Dmel\EP639^EP639

Species

D. melanogaster

Name

FlyBase ID

FBal0119697

Feature type

allele

Associated gene

EP639

Associated Insertion(s)

P{EP}EP639^EP639

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}EP639^EP639

Cytology

Description

P{EP} insertion at +480bp of EST SD02913. The P{EP} element is in antisense orientation relative to the transcription unit.

(Abdelilah-Seyfried et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,829,070..16,829,070 [+]

(Schulz et al., 2004, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

adult thorax, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

chaeta, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

germline cell | male, with Scer\GAL4^ptc-559.1

(Schulz et al., 2004)

macrochaeta, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

tormogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

wing, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

Detailed Description

Statement

Reference

Expression of BEST:SD02913^EP639 under the control of Scer\GAL4^ptc-559.1 (the animals are initially raised at 18^oC and then shifted to 29^oC after 10 days) results in a reduced number of early germ cells (stem cells, gonialblasts and spermatogonia) in the testis.

(Schulz et al., 2004)

Flies expressing BEST:SD02913^EP639 under the control of Scer\GAL4^ap-md544 have a slight thoracic cleft, misaligned bristles and deformed wings.

(Pena-Rangel et al., 2002)

Expression of BEST:SD02913^EP639 under the control of Scer\GAL4^sca-537.4 results in sensory organs with two sockets, two shafts and one sheath cell, one socket and two shafts and two sockets and one shaft. Loss of macrochaetae and abnormal shaft morphology is seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

EP639^EP639, Scer\GAL4^sca-537.4 has visible phenotype, suppressible by H^E21

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

EP639^EP639/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

EP639^EP639/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

EP639^EP639/Scer\GAL4^pnr-MD237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

EP639^EP639/Scer\GAL4^sca-537.4 is an enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Other

Statement

Reference

EP639^EP639, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has macrochaeta phenotype

(Pena-Rangel et al., 2002)

EP639^EP639, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

EP639^EP639, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has microchaeta phenotype

(Pena-Rangel et al., 2002)

EP639^EP639, Scer\GAL4^pnr-MD237, pnr^MD237 has macrochaeta phenotype

(Pena-Rangel et al., 2002)

EP639^EP639, Scer\GAL4^pnr-MD237, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

EP639^EP639, Scer\GAL4^pnr-MD237, pnr^MD237 has microchaeta phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing BEST:SD02913^EP639 under the control of Scer\GAL4^pnr-MD237 have a strong thoracic cleft, deformed scutellum, head defects and loss of several macrochaetae and microchaetae.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

BEST:SD02913^EP0639

BEST:SD02913^EP639

EP(2)0639

(Abdelilah-Seyfried et al., 2000)

EP639^EP639

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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