FlyBase Allele Report: Dmel\EP639[EP2437]

General Information

Symbol

Dmel\EP639^EP2437

Species

D. melanogaster

Name

FlyBase ID

FBal0119694

Feature type

allele

Associated gene

EP639

Associated Insertion(s)

P{EP}EP639^EP2437

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}EP639^EP2437

Cytology

Description

P{EP} insertion at +507p of EST SD02913. The P{EP} element is in antisense orientation relative to the transcription unit.

(Abdelilah-Seyfried et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,829,042..16,829,042 [+]

(Shulman and Feany, 2003, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

visible, with Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

adult thorax, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

chaeta, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

eye, with Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

macrochaeta, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

tormogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

wing, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

Detailed Description

Statement

Reference

Expression of BEST:SD02913^EP2437 under the control of Scer\GAL4^GMR.PF results in a very mild rough eye phenotype.

(Shulman and Feany, 2003)

Flies expressing BEST:SD02913^EP2437 under the control of Scer\GAL4^ap-md544 have a slight thoracic cleft, misaligned bristles and deformed wings.

(Pena-Rangel et al., 2002)

Expression of BEST:SD02913^EP2437 under the control of Scer\GAL4^sca-537.4 results in sensory organs with two sockets and two shafts and one socket and two shafts. Loss of macrochaetae and dot-like shaft morphology is seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

EP639^EP2437, Scer\GAL4^sca-537.4 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

EP639^EP2437, Scer\GAL4^sca-537.4 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

EP639^EP2437, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

EP639^EP2437/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

EP639^EP2437, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

EP639^EP2437, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

EP639^EP2437, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

EP639^EP2437, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

EP639^EP2437/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

EP639^EP2437/Scer\GAL4^pnr-MD237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

EP639^EP2437, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

EP639^EP2437/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT Suppressor of

Statement

Reference

EP639^EP2437, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Other

Statement

Reference

EP639^EP2437, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has macrochaeta phenotype

(Pena-Rangel et al., 2002)

EP639^EP2437, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

EP639^EP2437, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has microchaeta phenotype

(Pena-Rangel et al., 2002)

EP639^EP2437, Scer\GAL4^pnr-MD237, pnr^MD237 has macrochaeta phenotype

(Pena-Rangel et al., 2002)

EP639^EP2437, Scer\GAL4^pnr-MD237, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

EP639^EP2437, Scer\GAL4^pnr-MD237, pnr^MD237 has microchaeta phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing BEST:SD02913^EP2437 under the control of Scer\GAL4^pnr-MD237 have a strong thoracic cleft, deformed scutellum, head defects and loss of several macrochaetae and microchaetae.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by BEST:SD02913^EP2437.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

Comments

Precise excision of the P{EP} element reverts the modifying effect of BEST:SD02913^EP2437 on the rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Shulman and Feany, 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

BEST:SD02913^EP2437

EP(2)2437

(Abdelilah-Seyfried et al., 2000)

EP639^EP2437

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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