FB2024_03 , released June 25, 2024
Allele: Dmel\prosV2
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General Information
Symbol
Dmel\prosV2
Species
D. melanogaster
Name
FlyBase ID
FBal0105093
Feature type
allele
Associated gene
Dmel\pros
Associated Insertion(s)
P{GawB-Δ2.G}prosV2
Carried in Construct
Also Known As
Voila2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Grosjean et al., 2001, Balakireva et al., 2000)
Progenitor genotype
prosV1
(Grosjean et al., 2001, Balakireva et al., 2000)
Associated Insertion(s)
P{GawB-Δ2.G}prosV2
Cytology
Description

Imprecise excision of the P{GawB} element. Scer\GAL4 sequences are still present. w sequences are not detected. A 2.9kb BamHI-PstI fragment ("pBSK") from the 3' end of the element appears to be intact. Surrounding genomic sequences are unaffected.

(Grosjean et al., 2001)

Imprecise excision of the P{GawB} element.

(Balakireva et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The median lifespan for prosV2 animals (the age after egg laying at which 50% of homozygotes have died) is 7.57 days at 25oC.

      Homozygous second instar larvae are indifferent to 0.1M sucrose in a taste response assay, in contrast to wild-type larvae which are significantly attracted by sucrose. They are repulsed by 0.3M NaCl (as are wild-type larvae).

      (Grosjean et al., 2003)

      The courtship index of heterozygous males towards decapitated Canton-S males is not significantly different from that of wild-type males towards decapitated Canton-S males. Lethality of homozygotes occurs throughout most developmental stages.

      (Grosjean et al., 2001)

      Only a few homozygotes die during preimaginal development and more than 85% of homozygotes eclose. The surviving adults never survive for more than 48 hours after eclosion.

      (Balakireva et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Voila2
      (Grosjean et al., 2001, Balakireva et al., 2000)
      prosV2
      (Grosjean et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)