FB2024_03 , released June 25, 2024
Allele: Dmel\cyc02
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General Information
Symbol
Dmel\cyc02
Species
D. melanogaster
Name
cycle02
FlyBase ID
FBal0105033
Feature type
allele
Associated gene
Dmel\cyc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
chemical
(Park et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q113term.

(Park et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,815,020..19,815,020 [-]
Nucleotide change:

C19815020T

Reported nucleotide change:

C?T

Amino acid change:

Q113term | cyc-PA

Reported amino acid change:

Q113term

(Park et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      There is no significant increase in the time spent copulating by pairs of cyc02 homozygous flies compared to wild-type pairs.

      (Beaver and Giebultowicz, 2004)

      About a quarter of cyc0 adult brains exhibit an abnormal dorsal projection from the l-LNv cells. In about 30% of these mutant specimens the projections are asymmetric within a single individual: one hemisphere might contain a bundle of dorsally projected axons; but in the contralateral hemisphere, only one or two axons might project into the dorsal brain. In other cyc0 adults, axons stemming from the region project irregularly into a median brain region.

      (Park et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      cyc01

      (Park et al., 2000)
      Comments

      cyc01 and cyc02 are non complementing both for behaviour and for a severe reduction in levels of per protein.

      (Park et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cyc02
      (Bahn et al., 2009, Lee et al., 2006)
      cyc0
      (Park et al., 2000)
      Name Synonyms
      cycle02
      (Lee et al., 2006)
      Secondary FlyBase IDs
        References (5)