FB2024_03 , released June 25, 2024
Allele: Dmel\exdUAS.NLS.Tag:FLAG
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General Information
Symbol
Dmel\exdUAS.NLS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0104632
Feature type
allele
Associated gene
Dmel\exd
Associated Insertion(s)
Carried in Construct
P{UAS-NLS-exd}
Key Links
Transgenic product class
wild_type
(Jaw et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Jaw et al., 2000)
Mutagen
in vitro construct
(Jaw et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-NLS-exd}
Cytology
Description

The exd gene product is driven by UASt sequences and is tagged with a Nuclear localisation Signal (NLS) and Tag:FLAG.

(Jaw et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
exd
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When exdScer\UAS.NLS.T:Zzzz\FLAG expression is driven by Scer\GAL4dpp.blk1 the eyes and antenna of these flies are not affected, but the femur and tibia are deformed. Distal segments of the legs are never affected, even when flies are raised at 29oC.

      (Jaw et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      hthUAS.cPa, Scer\GAL4sca-537.4, exdUAS.NLS.Tag:FLAG is a non-suppressor of embryonic brain phenotype of UbxYAAA.UAS

      (Sprecher et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The defect in the embryonic tritocerebrum caused by expression of UbxScer\UAS.cCa under the control of Scer\GAL4sca-537.4 is completely suppressed if the embryos are also coexpressing both exdScer\UAS.NLS.T:Zzzz\FLAG and hthScer\UAS.cPa. The defect in the embryonic brain caused by expression of UbxYAAA.Scer\UAS under the control of Scer\GAL4sca-537.4 is not suppressed if the embryos are also coexpressing both exdScer\UAS.NLS.T:Zzzz\FLAG and hthScer\UAS.cPa.

      (Sprecher et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      exdScer\UAS.NLS.T:Zzzz\FLAG
      exdUAS.NLS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)