FB2024_03 , released June 25, 2024
Allele: Dmel\ci-3P.UAS.W.Tag:HA
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General Information
Symbol
Dmel\ci-3P.UAS.W.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0103880
Feature type
allele
Associated gene
Dmel\ci
Associated Insertion(s)
Carried in Construct
P{UAS-ci.HA.-3P}
Also Known As
UAS-HA-Ci-3P, UAS-ci-3P, HA-Ci-3P, UAS-HACi-3P
Key Links
Transgenic product class
missense_variant
(Wang et al., 1999)
polypeptide_post_translational_processing_variant
(Wang et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wang et al., 1999)
polypeptide_post_translational_processing_variant
(Wang et al., 1999)
Mutagen
in vitro construct
(Wang et al., 1999)
Progenitor genotype
ciUAS.W.Tag:HA
(Wang et al., 1999)
Carried in construct
P{UAS-ci.HA.-3P}
Cytology
Description

Mutations in the 3 PKA consensus phosphorylation sites; S838A, S856A and S892A.

(Wang et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ci
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA with rdxNIG.9924R
      (Gao et al., 2023)
      CEA with Mmus\Gli2UAS.Tag:MYC
      (Gao et al., 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ci-3P.Scer\UAS.W.T:Ivir\HA1 under the control of Scer\GAL4Bx-MS1096 results in overgrowth of the wing disc.

      (Zhang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing disc overgrowth phenotype caused by expression of ci-3P.Scer\UAS.W.T:Ivir\HA1 under the control of Scer\GAL4Bx-MS1096 is greatly enhanced by rdxΔ6, with the double mutant cells forming tumour-like overgrowths.

      Expression of ci-3P.Scer\UAS.W.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF in eyes carrying homozygous rdxΔ6 clones results in a severe rough eye phenotype.

      (Zhang et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ci-3P
      (Wang et al., 2000)
      Ci-PKA
      (Shi et al., 2014)
      ci-3P.Scer\UAS.W.T:Ivir\HA1
      ci-3P.UAS.W.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (14)