FB2024_03 , released June 25, 2024
Allele: Dmel\tacc1
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General Information
Symbol
Dmel\tacc1
Species
D. melanogaster
Name
FlyBase ID
FBal0103532
Feature type
allele
Associated gene
Dmel\tacc
Associated Insertion(s)
Carried in Construct
Also Known As
d-tacc1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gergely et al., 2000)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cycle 10 embryos from tacc1/Df(3R)Exel6142 mothers display a movement of yolk nuclei to the cortex associated with multiple free centrosomes.

      (Lattao et al., 2021)

      tacc1/Df(3R)110 embryos have a reduced number of pole cells compared to controls and the pole cells that do form often have greatly reduced germ plasm.

      (Lerit and Gavis, 2011)

      About one third of spindles in non-activated tacc1/Df(3R)110 oocytes have a tripolar spindle morphology. Pole focusing, spindle size and microtubule intensity seem to be normal.

      (Cullen and Ohkura, 2001)

      The number and length of the astral and spindle microtubules in metaphase spindles seems to be reduced in mutant embryos.

      (Lee et al., 2001)

      About 30-50% of embryos laid by tacc1/Df(3R)110 or (tacc1/Df(3R)ME15) mothers initiate development but die during early embryogenesis from an accumulation of mitotic defects, with may free centrosomes or aneuploid nuclei. Also the nuclei often fail to migrate to the cortex and remain tightly clustered in the middle of the embryo. Microtubules extending from the centrosome seem shorter than wild-type. The remainder of embryos arrest at the first mitotic division with a single spindle surrounding an apparently haploid set of nuclei. In these embryos the four female pronuclei seem to form normally but do not migrate to fuse with the male pronucleus.

      (Gergely et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Does not interact with alleles of sub.

      (Giunta et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      The tacc1 chromosome carries other recessive lethal mutations.

      (Cullen and Ohkura, 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (12)