FB2024_03 , released June 25, 2024
Allele: Dmel\RelUAS.Tag:polyHis
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General Information
Symbol
Dmel\RelUAS.Tag:polyHis
Species
D. melanogaster
Name
FlyBase ID
FBal0102860
Feature type
allele
Associated gene
Dmel\Rel
Associated Insertion(s)
Carried in Construct
P{UAS-Rel.His6}
Also Known As
UAS-Relish, UAS-Rel, P(UAS-Rel.His6)
Key Links
Transgenic product class
wild_type
(Hedengren et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hedengren et al., 1999)
Mutagen
in vitro construct
(Hedengren et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-Rel.His6}
Cytology
Description

UASt regulatory sequences drive expression of Rel tagged at the N-terminal end with Tag:polyHis.

(Hedengren et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rel
Tagged with
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  amyotrophic lateral sclerosis type 8
      modeled by Vap33Δ166, Vap33P58S.cRa.UAS
      (Tendulkar et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of RelScer\UAS.T:Zzzz\His6 under the control of Scer\GAL4repo has no significant effect on the number of apoptotic cells in the adult brain.

      (Petersen et al., 2013)

      Flies expressing RelScer\UAS.T:Zzzz\His6 via Scer\GAL4Cg.PA show lower levels of viral replication 5 days after intrathoracic infection with 200 pfu of Sindbis virus compared to controls.

      (Avadhanula et al., 2009)

      Expression of RelScer\UAS.T:Zzzz\His6 under the control of Scer\GAL4cad-md509 increases BrdU incorporation in the large and small cells in the adult posterior midgut, indicating an increase in cellular proliferation.

      (Choi et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      RelUAS.Tag:polyHis/Scer\GAL4hs.PB rescues RelE20

      (Hedengren et al., 1999)
      Partially rescues

      RelUAS.Tag:polyHis/Scer\GAL4Cg.PA partially rescues RelE20

      (Molaei et al., 2019)

      RelUAS.Tag:polyHis/Scer\GAL4c564 partially rescues RelE20

      (Ryu et al., 2006)

      RelUAS.Tag:polyHis/Scer\GAL4cad-em459 partially rescues RelE20

      (Ryu et al., 2006)
      Comments

      Expressing RelUAS.Tag:polyHis under the control of Scer\GAL4Cg.PA fully rescues lipid storage defects and only partially rescues the reduced resistance to starvation in RelE20/RelE20 adults.

      (Molaei et al., 2019)

      Expression of RelScer\UAS.T:Zzzz\His6 in the intestine, driven by Scer\GAL4cad-em459, results in the increased survival rate of RelE20 flies to control levels following infection with the ROS-resistant KNU53775 yeast strain. However, expression of RelScer\UAS.T:Zzzz\His6 in the fat body, driven by Scer\GAL4c564, does not increase the survival rates of RelE20 flies following KNU53775 infection. In contrast, expression of RelScer\UAS.T:Zzzz\His6 increases survival rates of RelE20 flies in response to infection with Erwinia carotovora carotovora 15 when driven by Scer\GAL4c564 but does not increase survival when driven with Scer\GAL4cad-em459.

      (Ryu et al., 2006)

      Rescues the immune defects of RelE20 flies when expressed under the control of Scer\GAL4hs.PB.

      (Hedengren et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RelScer\UAS.T:Zzzz\His6
      RelUAS.Tag:polyHis
      Name Synonyms
      Secondary FlyBase IDs
        References (18)