FB2024_03 , released June 25, 2024
Allele: Dmel\stanΔEX.UAS
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General Information
Symbol
Dmel\stanΔEX.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0101423
Feature type
allele
Associated gene
Dmel\stan
Associated Insertion(s)
Carried in Construct
P{UAS-fmi.ΔEX}
Key Links
Transgenic product class
inframe_deletion
(Usui et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Usui et al., 1999)
Mutagen
in vitro construct
(Usui et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-fmi.ΔEX}
Cytology
Description

Contains stan lacking almost the entire ectodomain (residues 56-2769) under the control of UAS sequences.

(Usui et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
stan
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Temperature- and dose-sensitive overexpression of stanΔEX.Scer\UAS with Scer\GAL4HLHmδ results in ommatidial axon cartridges containing abnormal numbers of R cell axons.

      (Chen and Clandinin, 2008)

      When transfected into a weakly aggregating S2 cell line, stanΔEX.Scer\UAS driven by Scer\GAL4Act5C.PHb fails to induce cell aggregation. When in expressed in the wing under the control of Scer\GAL4ptc-559.1, no effect is seen in the polarity of wing hairs.

      (Usui et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      stanΔEX.UAS partially rescues stan72/stanE59

      (Bao et al., 2007)
      Fails to rescue

      stanΔEX.UAS fails to rescue stan72/stanE59

      (Bao et al., 2007)
      Comments

      In stanE59/stan72 animals, neuronal expression of stanΔEX.Scer\UAS partially rescues the number of type II-innervated muscles from 70.5% to 55.7%, partially rescues the number of ectopic type I synapses from 14.8% to 8.8%, but does not rescue the loss of synaptic innervation of muscles 6, 7, 12 and 13.

      (Bao et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid and transfected into S2 cells, as a control, in order to study the effects of stan on cell aggregation.

      (Usui et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fmiΔEX.Scer\UAS
      (Usui et al., 1999)
      stanΔEX.Scer\UAS
      stanΔEX.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)