FB2024_03 , released June 25, 2024
Allele: Dmel\cim1-4.UAS.Tag:HA
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General Information
Symbol
Dmel\cim1-4.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0098771
Feature type
allele
Associated gene
Dmel\ci
Associated Insertion(s)
Carried in Construct
P{UAS-ci.HA.m1-4}
Also Known As
UAS-HACi(m1-4)
Key Links
Transgenic product class
missense_variant
(Chen et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chen et al., 1999)
Mutagen
in vitro construct
(Chen et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-ci.HA.m1-4}
Cytology
Description

ci is tagged at the N-terminus with Tag:HA. A mutated form of ci (carries the amino acid replacements S838A, S856A, S892A and T1006A) is expressed under the control of UASt regulatory sequences.

(Chen et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ci
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 10% of animals expressing cim1-4.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4prd.RG1 survive past the first instar stage. Embryos have cuticle defects; in alternating segments the posterior rows of denticles contain patches of naked cuticle and the anteriormost rows of denticle belts are missing denticles.

      (Chen et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Wing disc cells co-expressing armS10.Scer\UAS.T:Hsap\MYC and cim1-4.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Bx-MS1096 show a degree of hyperplastic overgrowth, but retain normal polarity and tissue architecture.

      (Skwarek et al., 2014)

      Expression of cim1-4.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL in ktoT663 clones in the wing disc does not rescue the boundary crossing behaviour seen in ktoT663 clones that touch the anterior-posterior boundary.

      (Janody et al., 2003)

      cim1-4.Scer\UAS.T:Ivir\HA1 partially rescues the hh21 lawn of denticles phenotype when expressed under the control of Scer\GAL4prd.RG1; embryos develop naked cuticle and the bordering denticles show some segmental organisation.

      (Chen et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      UAS-HA-Ci-4P
      (Dai et al., 2003)
      cim1-4.Scer\UAS.T:Ivir\HA1
      cim1-4.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (9)