FlyBase Allele Report: Dmel\Gαo[II.UAS]

General Information

Symbol

Dmel\Gαo^II.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0098390

Feature type

allele

Associated gene

Dmel\Gαo

Associated Insertion(s)

Carried in Construct

P{UAS-Gαo.II}

Key Links

Transgenic product class

cDNA

(Fremion et al., 1999)

wild_type

(Fremion et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Fremion et al., 1999)

wild_type

(Fremion et al., 1999)

Mutagen

in vitro construct

(Fremion et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-Gαo.II}

Cytology

Description

UASt regulatory sequences drive expression of the Gαo class II cDNA.

(Fremion et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Gαo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

neuroblast & spindle, with Scer\GAL4^{VP16.mat.αTub67C}

(Yu et al., 2003)

Detailed Description

Statement

Reference

Overexpression of G-oα47A^II.Scer\UAS under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in 85% of neuroblasts exhibiting equal-size divisions, with spindle geometry late in mitosis remaining symmetric.

(Yu et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^how-24B/Gαo^II.UAS partially rescues Df(2R)47A

(Fremion et al., 1999)

Scer\GAL4^how-24B/Gαo^II.UAS partially rescues Gαo⁰⁰⁷

(Fremion et al., 1999)

Comments

The heart and visceral mesoderm defects, but not the nervous system defects, of Df(2R)47A embryos are rescued in 65% of cases by G-oα47A^II.Scer\UAS expressed under the control of Scer\GAL4^how-24B. 80% of G-oα47A⁰⁰⁷ embryos are rescued by G-oα47A^II.Scer\UAS expressed under the control of Scer\GAL4^how-24B.

(Fremion et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

G-oα47A^II.Scer\UAS

Gαo^II.Scer\UAS

Gαo^II.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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