FlyBase Allele Report: Dmel\dock[unspecified]

General Information

Symbol

Dmel\dock^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0098256

Feature type

allele

Associated gene

Dmel\dock

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

lamina

(Hing et al., 1999)

medulla

(Hing et al., 1999)

photoreceptor cell & axon

(Hing et al., 1999)

photoreceptor cell & axon | somatic clone

(Newsome et al., 2000)

Detailed Description

Statement

Reference

Defects in pathfinding by photoreceptor axons are seen in mosaic animals in which virtually the entire retina is homozygous for dock^unspecified while other tissues are heterozygous (clones generated using the "eyFLP" system); 77% of brain hemispheres of mosaic adults show a "medulla bypass" phenotype.

(Newsome et al., 2000)

R cell axons form large abnormal fascicles in the optic ganglia. This leads to hyperinnervated regions separated by areas lacking innervation in the lamina and the medulla. In addition to disrupting targeting, R cell axons terminals are thick and blunt ended.

(Hing et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

dock^unspecified has photoreceptor cell & axon phenotype, suppressible by Pak^{GMR.Tag:Myr(Src64B)}

(Hing et al., 1999)

dock^unspecified has lamina phenotype, suppressible by Pak^{GMR.Tag:Myr(Src64B)}

(Hing et al., 1999)

dock^unspecified has medulla phenotype, suppressible by Pak^{GMR.Tag:Myr(Src64B)}

(Hing et al., 1999)

NOT suppressed by

Statement

Reference

dock^unspecified has phenotype, non-suppressible by Pak^GMR.PH

(Hing et al., 1999)

dock^unspecified has phenotype, non-suppressible by Pak^{K459A.GMR.Tag:Myr(Src64B)}

(Hing et al., 1999)

dock^unspecified has phenotype, non-suppressible by Pak^L115F.GMR

(Hing et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Pak^GMR.T:Myr1 in dock^unspecified larvae, suppresses the dock phenotype of gaps in the lamina, abnormal axon bundling and unexpanded growth cones in the medulla. Quantification of the expanded growth cones in the medulla showed an increase from less than 2 to 64+/-8 (136+/-12 in wild-type).

(Hing et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dock^unspecified is rescued by dock^GMR.PG

(Garrity et al., 1996)

dock^unspecified is rescued by dock^hs.PG

(Garrity et al., 1996)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dock^unspecified

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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