FB2024_03 , released June 25, 2024
Allele: Dmel\inscA2-A3.hs.Tag:FLAG
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General Information
Symbol
Dmel\inscA2-A3.hs.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0096881
Feature type
allele
Associated gene
Dmel\insc
Associated Insertion(s)
Carried in Construct
P{hs-insc.A2-A3}
Key Links
Transgenic product class
inframe_deletion
(Tio et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Tio et al., 1999)
Mutagen
in vitro construct
(Tio et al., 1999)
Progenitor genotype
Carried in construct
P{hs-insc.A2-A3}
Cytology
Description

A heat shock promoter drives expression of amino acids 288 to 497 of insc tagged with Tag:FLAG.

(Tio et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
insc
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ectodermal cells of embryos ectopically expressing inscA2-A3.hs.T:Zzzz\FLAG show reorientation of their mitotic spindles so that they are perpendicular to the apical surface of the embryo. Embryos expressing inscA2-A3.hs.T:Zzzz\FLAG show gross morphological defects late in development, including a high frequency of RP2 neuron loss, occasional reduction or loss of EL clusters, a general spatial disorder of the central nervous system, and defects in gut development.

      (Tio et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      inscA2-A3.hs.T:Zzzz\FLAG
      inscA2-A3.hs.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)