Nucleotide substitution: A250T.
Amino acid replacement: ?84term.
Homozygous embryos show no obvious axonal phenotypes under standard temperature conditions. If the embryos are allowed to develop at 4oC for 1 day, a fused commissure phenotype develops.
Mutant embryos show a clear fusion of commissures and frequent disruption of longitudinal connectives. Midline glial cells are either reduce in number or fail to properly migrate in between anterior and posterior commissures. General embryonic morphology is relatively normal, though the PNS shows a slight reduction in sensory neurons and defects in the trajectories of motoneurons.
α-SpecE2-26 is rescued by α-SpecRpS27A.PL
Embryos homozygous for the original α-SpecE2-26 chromosome (which contained background mutations) have an axonal phenotype (partially fused commissures), but α-SpecE2-26 homozygotes in which the background mutations have been removed from the chromosome show no axonal phenotypes under standard temperature conditions.
Separable from: Background lethal mutations.
